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Inhibition of heme uptake in Pseudomonas aeruginosa by its hemophore (HasA(p)) bound to synthetic metal complexes.

Shirataki C, Shoji O, Terada M, Ozaki S, Sugimoto H, Shiro Y, Watanabe Y
Angew Chem Int Ed Engl 53 2862-6 (2014)
Related entries: 3w8m, 3w8o

Cited: 12 times
EuropePMC logo PMID: 24604808

Abstract

The heme acquisition system A protein secreted by Pseudomonas aeruginosa (HasA(p)) can capture several synthetic metal complexes other than heme. The crystal structures of HasA(p) harboring synthetic metal complexes revealed only small perturbation of the overall HasA(p) structure. An inhibitory effect upon heme acquisition by HasA(p) bearing synthetic metal complexes was examined by monitoring the growth of Pseudomonas aeruginosa PAO1. HasA(p) bound to iron-phthalocyanine inhibits heme acquisition in the presence of heme-bound HasA(p) as an iron source.

Reviews citing this publication (3)

  1. Extracellular Heme Uptake and the Challenge of Bacterial Cell Membranes. Huang W, Wilks A. Annu Rev Biochem 86 799-823 (2017)
  2. Chemical and Biological Aspects of Nutritional Immunity-Perspectives for New Anti-Infectives that Target Iron Uptake Systems. Bilitewski U, Blodgett JAV, Duhme-Klair AK, Dallavalle S, Laschat S, Routledge A, Schobert R. Angew Chem Int Ed Engl 56 14360-14382 (2017)
  3. Metallotherapeutics development in the age of iron-clad bacteria. Centola G, Xue F, Wilks A. Metallomics 12 1863-1877 (2020)

Articles citing this publication (9)

  1. Gallium(III)-Salophen as a Dual Inhibitor of Pseudomonas aeruginosa Heme Sensing and Iron Acquisition. Centola G, Deredge DJ, Hom K, Ai Y, Dent AT, Xue F, Wilks A. ACS Infect Dis 6 2073-2085 (2020)
  2. Sensitive quantification of carbon monoxide in vivo reveals a protective role of circulating hemoglobin in CO intoxication. Mao Q, Kawaguchi AT, Mizobata S, Motterlini R, Foresti R, Kitagishi H. Commun Biol 4 425 (2021)
  3. The Small Protein HemP Is a Transcriptional Activator for the Hemin Uptake Operon in Burkholderia multivorans ATCC 17616. Sato T, Nonoyama S, Kimura A, Nagata Y, Ohtsubo Y, Tsuda M. Appl Environ Microbiol 83 e00479-17 (2017)
  4. Iron/Heme Metabolism-Targeted Gallium(III) Nanoparticles Are Active against Extracellular and Intracellular Pseudomonas aeruginosa and Acinetobacter baumannii. Choi SR, Britigan BE, Narayanasamy P. Antimicrob Agents Chemother 63 e02643-18 (2019)
  5. Structures of the Heme Acquisition Protein HasA with Iron(III)-5,15-Diphenylporphyrin and Derivatives Thereof as an Artificial Prosthetic Group. Uehara H, Shisaka Y, Nishimura T, Sugimoto H, Shiro Y, Miyake Y, Shinokubo H, Watanabe Y, Shoji O. Angew Chem Int Ed Engl 56 15279-15283 (2017)
  6. Designer Heme Proteins: Achieving Novel Function with Abiological Heme Analogues. Lemon CM, Marletta MA. Acc Chem Res 54 4565-4575 (2021)
  7. Corrole-Substituted Fluorescent Heme Proteins. Lemon CM, Marletta MA. Inorg Chem 60 2716-2729 (2021)
  8. Corrole-protein interactions in H-NOX and HasA. Lemon CM, Nissley AJ, Latorraca NR, Wittenborn EC, Marletta MA. RSC Chem Biol 3 571-581 (2022)
  9. Highly malleable haem-binding site of the haemoprotein HasA permits stable accommodation of bulky tetraphenylporphycenes. Sakakibara E, Shisaka Y, Onoda H, Koga D, Xu N, Ono T, Hisaeda Y, Sugimoto H, Shiro Y, Watanabe Y, Shoji O. RSC Adv 9 18697-18702 (2019)


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