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Crystal structure of HypE-HypF complex

Source organism: Caldanaerobacter subterraneus subsp. tengcongensis MB4
Biochemical function: metal ion binding
Biological process: protein maturation
Cellular component: not assigned

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EC 3.6.1.7: Acylphosphatase

Reaction catalysed:
An acylphosphate + H(2)O = a carboxylate + phosphate
Systematic name:
Acylphosphate phosphohydrolase
Alternative Name(s):
  • 1,3-diphosphoglycerate phosphatase
  • Acetic phosphatase
  • Acetylphosphatase
  • GP 1-3
  • Ho 1-3

GO terms

Sequence families

Pfam Protein families (Pfam)
PF07503
Domain description: HypF finger
Occurring in:
  1. Carbamoyltransferase
The deposited structure of PDB entry 3vti contains 4 copies of Pfam domain PF07503 (HypF finger) in Carbamoyltransferase. Showing 2 copies in chain A.

PF02769
Domain description: AIR synthase related protein, C-terminal domain
Occurring in:
  1. Hydrogenase maturation factor
The deposited structure of PDB entry 3vti contains 2 copies of Pfam domain PF02769 (AIR synthase related protein, C-terminal domain) in Hydrogenase maturation factor. Showing 1 copy in chain C.

PF00586
Domain description: AIR synthase related protein, N-terminal domain
Occurring in:
  1. Hydrogenase maturation factor
The deposited structure of PDB entry 3vti contains 2 copies of Pfam domain PF00586 (AIR synthase related protein, N-terminal domain) in Hydrogenase maturation factor. Showing 1 copy in chain C.

PF17788
Domain description: HypF Kae1-like domain
Occurring in:
  1. Carbamoyltransferase
The deposited structure of PDB entry 3vti contains 2 copies of Pfam domain PF17788 (HypF Kae1-like domain) in Carbamoyltransferase. Showing 1 copy in chain A.

PF01300
Domain description: Telomere recombination
Occurring in:
  1. Carbamoyltransferase
The deposited structure of PDB entry 3vti contains 2 copies of Pfam domain PF01300 (Telomere recombination) in Carbamoyltransferase. Showing 1 copy in chain A.

PF00708
Domain description: Acylphosphatase
Occurring in:
  1. Carbamoyltransferase
The deposited structure of PDB entry 3vti contains 2 copies of Pfam domain PF00708 (Acylphosphatase) in Carbamoyltransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR011854
Domain description: Carbamoyl dehydratase HypE
Occurring in:
  1. Hydrogenase maturation factor
IPR036676
Domain description: PurM-like, C-terminal domain superfamily
Occurring in:
  1. Hydrogenase maturation factor
IPR036921
Domain description: PurM-like, N-terminal domain superfamily
Occurring in:
  1. Hydrogenase maturation factor
IPR006070
Domain description: Threonylcarbamoyl-AMP synthase-like domain
Occurring in:
  1. Carbamoyltransferase
IPR011125
Domain description: Zinc finger, HypF-type
Occurring in:
  1. Carbamoyltransferase
IPR001792
Domain description: Acylphosphatase-like domain
Occurring in:
  1. Carbamoyltransferase
IPR004421
Domain description: Carbamoyltransferase, HypF-type
Occurring in:
  1. Carbamoyltransferase
IPR010918
Domain description: PurM-like, C-terminal domain
Occurring in:
  1. Hydrogenase maturation factor
IPR016188
Domain description: PurM-like, N-terminal domain
Occurring in:
  1. Hydrogenase maturation factor
IPR043129
Domain description: ATPase, nucleotide binding domain
Occurring in:
  1. Carbamoyltransferase
IPR041440
Domain description: HypF, Kae1-like domain
Occurring in:
  1. Carbamoyltransferase
IPR017945
Domain description: DHBP synthase RibB-like alpha/beta domain superfamily
Occurring in:
  1. Carbamoyltransferase
IPR017968
Domain description: Acylphosphatase, conserved site
Occurring in:
  1. Carbamoyltransferase
IPR036046
Domain description: Acylphosphatase-like domain superfamily
Occurring in:
  1. Carbamoyltransferase

Structure domains

CATH CATH domains
3.30.420.560
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Nucleotidyltransferase; domain 5
Homology: Nucleotidyltransferase; domain 5
Occurring in:
  1. Carbamoyltransferase
The deposited structure of PDB entry 3vti contains 2 copies of CATH domain 3.30.420.560 (Nucleotidyltransferase; domain 5) in Carbamoyltransferase. Showing 1 copy in chain A.
3.30.420.360
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Nucleotidyltransferase; domain 5
Homology: Nucleotidyltransferase; domain 5
Occurring in:
  1. Carbamoyltransferase
The deposited structure of PDB entry 3vti contains 2 copies of CATH domain 3.30.420.360 (Nucleotidyltransferase; domain 5) in Carbamoyltransferase. Showing 1 copy in chain A.
3.30.110.120
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Translation Initiation Factor IF3
Homology: Translation Initiation Factor IF3
Occurring in:
  1. Carbamoyltransferase
The deposited structure of PDB entry 3vti contains 2 copies of CATH domain 3.30.110.120 (Translation Initiation Factor IF3) in Carbamoyltransferase. Showing 1 copy in chain A.
3.90.870.40
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: DHBP synthase
Homology: DHBP synthase
Occurring in:
  1. Carbamoyltransferase
The deposited structure of PDB entry 3vti contains 2 copies of CATH domain 3.90.870.40 (DHBP synthase) in Carbamoyltransferase. Showing 1 copy in chain A.
3.90.650.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Phosphoribosyl-aminoimidazole Synthetase; Chain A, domain 2
Homology: PurM-like C-terminal domain
Occurring in:
  1. Hydrogenase maturation factor
The deposited structure of PDB entry 3vti contains 2 copies of CATH domain 3.90.650.10 (Phosphoribosyl-aminoimidazole Synthetase; Chain A, domain 2) in Hydrogenase maturation factor. Showing 1 copy in chain C.
3.30.1330.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: 60s Ribosomal Protein L30; Chain: A;
Homology: PurM-like, N-terminal domain
Occurring in:
  1. Hydrogenase maturation factor
The deposited structure of PDB entry 3vti contains 2 copies of CATH domain 3.30.1330.10 (60s Ribosomal Protein L30; Chain: A;) in Hydrogenase maturation factor. Showing 1 copy in chain C.
1.10.357.160
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Tetracycline Repressor; domain 2
Homology: Tetracycline Repressor; domain 2
Occurring in:
  1. Carbamoyltransferase
The deposited structure of PDB entry 3vti contains 2 copies of CATH domain 1.10.357.160 (Tetracycline Repressor; domain 2) in Carbamoyltransferase. Showing 1 copy in chain A.
3.30.70.100
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Alpha-Beta Plaits
Occurring in:
  1. Carbamoyltransferase
The deposited structure of PDB entry 3vti contains 2 copies of CATH domain 3.30.70.100 (Alpha-Beta Plaits) in Carbamoyltransferase. Showing 1 copy in chain A.

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