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Stereospecific formation of a ternary complex of (S)-α,β-fluoromethylene-dATP with DNA pol β.

Chamberlain BT, Batra VK, Beard WA, Kadina AP, Shock DD, Kashemirov BA, McKenna CE, Goodman MF, Wilson SH
Chembiochem 13 528-30 (2012)
Cited: 12 times
EuropePMC logo PMID: 22315190

Abstract

The influence of water: crystallization of (R/S)-α,β-CHF-dATP with the preorganized pol β-DNA complex shows that (S)-α,β-CHF-dATP is preferentially bound to the active site with the C=F fluorine proximal to a structural water bound to Asp276.

Articles - 3tfr mentioned but not cited (2)

  1. Stereospecific formation of a ternary complex of (S)-α,β-fluoromethylene-dATP with DNA pol β. Chamberlain BT, Batra VK, Beard WA, Kadina AP, Shock DD, Kashemirov BA, McKenna CE, Goodman MF, Wilson SH. Chembiochem 13 528-530 (2012)
  2. The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins. Chakraborty S, Rendón-Ramírez A, Ásgeirsson B, Dutta M, Ghosh AS, Oda M, Venkatramani R, Rao BJ, Dandekar AM, Goñi FM. F1000Res 2 286 (2013)


Reviews citing this publication (1)

  1. Reflections on biocatalysis involving phosphorus. Blackburn GM, Bowler MW, Jin Y, Waltho JP. Biochemistry (Mosc) 77 1083-1096 (2012)

Articles citing this publication (9)

  1. Structures of dNTP intermediate states during DNA polymerase active site assembly. Freudenthal BD, Beard WA, Wilson SH. Structure 20 1829-1837 (2012)
  2. Small molecule inhibition of SAMHD1 dNTPase by tetramer destabilization. Seamon KJ, Hansen EC, Kadina AP, Kashemirov BA, McKenna CE, Bumpus NN, Stivers JT. J Am Chem Soc 136 9822-9825 (2014)
  3. Transition state in DNA polymerase β catalysis: rate-limiting chemistry altered by base-pair configuration. Oertell K, Chamberlain BT, Wu Y, Ferri E, Kashemirov BA, Beard WA, Wilson SH, McKenna CE, Goodman MF. Biochemistry 53 1842-1848 (2014)
  4. Effect of β,γ-CHF- and β,γ-CHCl-dGTP halogen atom stereochemistry on the transition state of DNA polymerase β. Oertell K, Wu Y, Zakharova VM, Kashemirov BA, Shock DD, Beard WA, Wilson SH, McKenna CE, Goodman MF. Biochemistry 51 8491-8501 (2012)
  5. Remarkably Stereospecific Utilization of ATP α,β-Halomethylene Analogues by Protein Kinases. Ni F, Kung A, Duan Y, Shah V, Amador CD, Guo M, Fan X, Chen L, Chen Y, McKenna CE, Zhang C. J Am Chem Soc 139 7701-7704 (2017)
  6. Structural basis for the inefficient nucleotide incorporation opposite cisplatin-DNA lesion by human DNA polymerase β. Koag MC, Lai L, Lee S. J Biol Chem 289 31341-31348 (2014)
  7. Two Scaffolds from Two Flips: (α,β)/(β,γ) CH2/NH "Met-Im" Analogues of dTTP. Kadina AP, Kashemirov BA, Oertell K, Batra VK, Wilson SH, Goodman MF, McKenna CE. Org Lett 17 2586-2589 (2015)
  8. Structural insights into the promutagenic bypass of the major cisplatin-induced DNA lesion. Ouzon-Shubeita H, Vilas CK, Lee S. Biochem J 477 937-951 (2020)
  9. Unexpected loss of stereoselectivity in ring-opening reaction of 2-alkoxy-2-thio-1,3,2-oxathiaphospholanes with a pyrophosphate anion. Guga P, Tomaszewska A. Chirality 27 115-122 (2015)


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