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Activation of the Human Nuclear Xenobiotic Receptor PXR by the Reverse Transcriptase-Targeted Anti-HIV Drug PNU-142721

Source organism: Homo sapiens
Biochemical function: nuclear receptor activity
Biological process: regulation of DNA-templated transcription
Cellular component: not assigned

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EC 2.3.1.48: Histone acetyltransferase

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Systematic name:
Acetyl-CoA:[protein]-L-lysine acetyltransferase
Alternative Name(s):
  • Acetyl-CoA:histone acetyltransferase
  • Histone acetokinase
  • Histone acetylase
  • Histone transacetylase
  • Lysine acetyltransferase
  • Nucleosome-histone acetyltransferase
  • Protein lysine acetyltransferase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00104
Domain description: Ligand-binding domain of nuclear hormone receptor
Occurring in:
  1. Nuclear receptor subfamily 1 group I member 2
The deposited structure of PDB entry 3r8d contains 1 copy of Pfam domain PF00104 (Ligand-binding domain of nuclear hormone receptor) in Nuclear receptor subfamily 1 group I member 2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001723
Domain description: Nuclear hormone receptor
Occurring in:
  1. Nuclear receptor subfamily 1 group I member 2
IPR001728
Domain description: Thyroid hormone receptor
Occurring in:
  1. Nuclear receptor subfamily 1 group I member 2
IPR000536
Domain description: Nuclear hormone receptor, ligand-binding domain
Occurring in:
  1. Nuclear receptor subfamily 1 group I member 2
IPR035500
Domain description: Nuclear hormone receptor-like domain superfamily
Occurring in:
  1. Nuclear receptor subfamily 1 group I member 2

Structure domain

CATH CATH domain
1.10.565.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Retinoid X Receptor
Homology: Retinoid X Receptor
Occurring in:
  1. Nuclear receptor subfamily 1 group I member 2
The deposited structure of PDB entry 3r8d contains 1 copy of CATH domain 1.10.565.10 (Retinoid X Receptor) in Nuclear receptor subfamily 1 group I member 2. Showing 1 copy in chain A.

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