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Crystal structure of pyrophosphatase from bacteroides thetaiotaomicron, an open cap conformation

Source organism: Bacteroides thetaiotaomicron
Biochemical function: sugar-phosphatase activity
Biological process: not assigned
Cellular component: not assigned

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EC 3.6.1.1: Inorganic diphosphatase

Reaction catalysed:
Diphosphate + H(2)O = 2 phosphate
Systematic name:
Diphosphate phosphohydrolase
Alternative Name(s):
  • Inorganic pyrophosphatase
  • Pyrophosphate phosphohydrolase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF13419
Domain description: Haloacid dehalogenase-like hydrolase
Occurring in:
  1. Beta-phosphoglucomutase
The deposited structure of PDB entry 3quq contains 1 copy of Pfam domain PF13419 (Haloacid dehalogenase-like hydrolase) in Beta-phosphoglucomutase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006439
Domain description: HAD hydrolase, subfamily IA
Occurring in:
  1. Beta-phosphoglucomutase
IPR023198
Domain description: Phosphoglycolate phosphatase-like, domain 2
Occurring in:
  1. Beta-phosphoglucomutase
IPR023214
Domain description: HAD superfamily
Occurring in:
  1. Beta-phosphoglucomutase
IPR041492
Domain description: Haloacid dehalogenase-like hydrolase
Occurring in:
  1. Beta-phosphoglucomutase
IPR036412
Domain description: HAD-like superfamily
Occurring in:
  1. Beta-phosphoglucomutase
IPR008916
Domain description: Retrovirus capsid, C-terminal
Occurring in:
  1. Beta-phosphoglucomutase

Structure domains

CATH CATH domains
3.40.50.1000
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: HAD superfamily/HAD-like
Occurring in:
  1. Beta-phosphoglucomutase
The deposited structure of PDB entry 3quq contains 1 copy of CATH domain 3.40.50.1000 (Rossmann fold) in Beta-phosphoglucomutase. Showing 1 copy in chain A.
1.10.150.240
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: DNA polymerase; domain 1
Homology: Putative phosphatase; domain 2
Occurring in:
  1. Beta-phosphoglucomutase
The deposited structure of PDB entry 3quq contains 1 copy of CATH domain 1.10.150.240 (DNA polymerase; domain 1) in Beta-phosphoglucomutase. Showing 1 copy in chain A.

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