3mrr › Citations

Analysis of relationships between peptide/MHC structural features and naive T cell frequency in humans.

Reiser JB, Legoux F, Gras S, Trudel E, Chouquet A, Léger A, Le Gorrec M, Machillot P, Bonneville M, Saulquin X, Housset D
J Immunol 193 5816-26 (2014)
Related entries: 3mrc, 3mrd, 3mre, 3mrg, 3mrh, 3mrl, 3mro

Cited: 16 times
EuropePMC logo PMID: 25392532

Abstract

The structural rules governing peptide/MHC (pMHC) recognition by T cells remain unclear. To address this question, we performed a structural characterization of several HLA-A2/peptide complexes and assessed in parallel their antigenicity, by analyzing the frequency of the corresponding Ag-specific naive T cells in A2(+) and A2(-) individuals, as well as within CD4(+) and CD8(+) subsets. We were able to find a correlation between specific naive T cell frequency and peptide solvent accessibility and/or mobility for a subset of moderately prominent peptides. However, one single structural parameter of the pMHC complexes could not be identified to explain each peptide antigenicity. Enhanced pMHC antigenicity was associated with both highly biased TRAV usage, possibly reflecting favored interaction between particular pMHC complexes and germline TRAV loops, and peptide structural features allowing interactions with a broad range of permissive CDR3 loops. In this context of constrained TCR docking mode, an optimal peptide solvent exposed surface leading to an optimal complementarity with TCR interface may constitute one of the key features leading to high frequency of specific T cells. Altogether our results suggest that frequency of specific T cells depends on the fine-tuning of several parameters, the structural determinants governing TCR-pMHC interaction being just one of them.

Articles - 3mrr mentioned but not cited (2)

  1. Broad TCR repertoire and diverse structural solutions for recognition of an immunodominant CD8+ T cell epitope. Song I, Gil A, Mishra R, Ghersi D, Selin LK, Stern LJ. Nat Struct Mol Biol 24 395-406 (2017)
  2. Integrated bioinformatics and statistical approaches to explore molecular biomarkers for breast cancer diagnosis, prognosis and therapies. Alam MS, Sultana A, Reza MS, Amanullah M, Kabir SR, Mollah MNH. PLoS One 17 e0268967 (2022)


Reviews citing this publication (1)

  1. Structural Prediction of Peptide-MHC Binding Modes. Perez MAS, Cuendet MA, Röhrig UF, Michielin O, Zoete V. Methods Mol Biol 2405 245-282 (2022)

Articles citing this publication (13)

  1. The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses. Jongsma MLM, de Waard AA, Raaben M, Zhang T, Cabukusta B, Platzer R, Blomen VA, Xagara A, Verkerk T, Bliss S, Kong X, Gerke C, Janssen L, Stickel E, Holst S, Plomp R, Mulder A, Ferrone S, Claas FHJ, Heemskerk MHM, Griffioen M, Halenius A, Overkleeft H, Huppa JB, Wuhrer M, Brummelkamp TR, Neefjes J, Spaapen RM. Immunity 54 132-150.e9 (2021)
  2. Previously Hidden Dynamics at the TCR-Peptide-MHC Interface Revealed. Fodor J, Riley BT, Borg NA, Buckle AM. J Immunol 200 4134-4145 (2018)
  3. A Diverse Lipid Antigen-Specific TCR Repertoire Is Clonally Expanded during Active Tuberculosis. DeWitt WS, Yu KKQ, Wilburn DB, Sherwood A, Vignali M, Day CL, Scriba TJ, Robins HS, Swanson WJ, Emerson RO, Bradley PH, Seshadri C. J Immunol 201 888-896 (2018)
  4. Lack of Heterologous Cross-reactivity toward HLA-A*02:01 Restricted Viral Epitopes Is Underpinned by Distinct αβT Cell Receptor Signatures. Grant EJ, Josephs TM, Valkenburg SA, Wooldridge L, Hellard M, Rossjohn J, Bharadwaj M, Kedzierska K, Gras S. J Biol Chem 291 24335-24351 (2016)
  5. Impaired Priming of SARS-CoV-2-Specific Naive CD8+ T Cells in Older Subjects. Gallerani E, Proietto D, Dallan B, Campagnaro M, Pacifico S, Albanese V, Marzola E, Marconi P, Caputo A, Appay V, Gavioli R, Nicoli F. Front Immunol 12 693054 (2021)
  6. Role of the MHC restriction during maturation of antigen-specific human T cells in the thymus. Hesnard L, Legoux F, Gautreau L, Moyon M, Baron O, Devilder MC, Bonneville M, Saulquin X. Eur J Immunol 46 560-569 (2016)
  7. Inability To Detect Cross-Reactive Memory T Cells Challenges the Frequency of Heterologous Immunity among Common Viruses. Rowntree LC, Nguyen THO, Halim H, Purcell AW, Rossjohn J, Gras S, Kotsimbos TC, Mifsud NA. J Immunol 200 3993-4003 (2018)
  8. An Engineered T Cell Receptor Variant Realizes the Limits of Functional Binding Modes. Singh NK, Alonso JA, Harris DT, Anderson SD, Ma J, Hellman LM, Rosenberg AM, Kolawole EM, Evavold BD, Kranz DM, Baker BM. Biochemistry 59 4163-4175 (2020)
  9. Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes. Walters LC, Rozbesky D, Harlos K, Quastel M, Sun H, Springer S, Rambo RP, Mohammed F, Jones EY, McMichael AJ, Gillespie GM. Cell Rep 39 110959 (2022)
  10. The Structure and Mechanism of Drug Transporters. Roberts AG. Methods Mol Biol 2342 193-234 (2021)
  11. Prediction of peptide binding to a major histocompatibility complex class I molecule based on docking simulation. Ishikawa T. J Comput Aided Mol Des 30 875-887 (2016)
  12. Xeno interactions between MHC-I proteins and molecular chaperones enable ligand exchange on a broad repertoire of HLA allotypes. Sun Y, Papadaki GF, Devlin CA, Danon JN, Young MC, Winters TJ, Burslem GM, Procko E, Sgourakis NG. Sci Adv 9 eade7151 (2023)
  13. Molecular Characterization of MHC Class I Alpha 1 and 2 Domains in Asian Seabass (Lates calcarifer). Loh Z, Huan X, Awate S, Schrittwieser M, Renia L, Ren EC. Int J Mol Sci 23 10688 (2022)


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