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Crystal structure of human phosphodiesterase 4d with rolipram

Source organism: Homo sapiens
Biochemical function: phosphoric diester hydrolase activity
Biological process: signal transduction
Cellular component: not assigned

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EC 3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase

Reaction catalysed:
Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate
Systematic name:
3',5'-cyclic-AMP 5'-nucleotidohydrolase
Alternative Name(s):
  • PDE1
  • PDE2A
  • PDE2B
  • PDE4
  • PDE7
  • PDE8
  • PDEB1
  • PDEB2
  • cAMP-specific PDE
  • cAMP-specific phosphodiesterase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00233
Domain description: 3'5'-cyclic nucleotide phosphodiesterase
Occurring in:
  1. 3',5'-cyclic-AMP phosphodiesterase 4D
The deposited structure of PDB entry 3g4k contains 4 copies of Pfam domain PF00233 (3'5'-cyclic nucleotide phosphodiesterase) in 3',5'-cyclic-AMP phosphodiesterase 4D. Showing 1 copy in chain D.

InterPro InterPro annotations
IPR023088
Domain description: 3'5'-cyclic nucleotide phosphodiesterase
Occurring in:
  1. 3',5'-cyclic-AMP phosphodiesterase 4D
IPR002073
Domain description: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Occurring in:
  1. 3',5'-cyclic-AMP phosphodiesterase 4D
IPR023174
Domain description: 3'5'-cyclic nucleotide phosphodiesterase, conserved site
Occurring in:
  1. 3',5'-cyclic-AMP phosphodiesterase 4D
IPR003607
Domain description: HD/PDEase domain
Occurring in:
  1. 3',5'-cyclic-AMP phosphodiesterase 4D
IPR036971
Domain description: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
Occurring in:
  1. 3',5'-cyclic-AMP phosphodiesterase 4D

Structure domain

CATH CATH domain
1.10.1300.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
Homology: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Occurring in:
  1. 3',5'-cyclic-AMP phosphodiesterase 4D
The deposited structure of PDB entry 3g4k contains 4 copies of CATH domain 1.10.1300.10 (Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b) in 3',5'-cyclic-AMP phosphodiesterase 4D. Showing 1 copy in chain D.

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