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Crystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: implications for biological assembly and inhibitor development.

Pilka ES, Kochan G, Oppermann U, Yue WW
Biochem Biophys Res Commun 419 485-9 (2012)
Cited: 33 times
EuropePMC logo PMID: 22366092

Abstract

Zn(2+)-dependent carbonic anhydrases (CA) catalyse the reversible hydration of carbon dioxide to bicarbonate and participate in diverse physiological processes, hence having manifold therapeutic potentials. Among the 15 human CAs with wide-ranging sub-cellular localisation and kinetic properties, CA VI is the only secretory isoform. The 1.9Å crystal structure of the human CA VI catalytic domain reveals a prototypical mammalian CA fold, and a novel dimeric arrangement as compared to previously-reported CA structures. The active site cavity contains a cluster of non-conserved residues that may be involved in ligand binding and have significant implications for developing the next-generation of isoform-specific inhibitors.

Reviews - 3fe4 mentioned but not cited (1)

  1. Crystallography and Its Impact on Carbonic Anhydrase Research. Lomelino CL, Andring JT, McKenna R. Int J Med Chem 2018 9419521 (2018)

Articles - 3fe4 mentioned but not cited (9)

  1. Insights towards sulfonamide drug specificity in α-carbonic anhydrases. Aggarwal M, Kondeti B, McKenna R. Bioorg Med Chem 21 1526-1533 (2013)
  2. Structural and biophysical characterization of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2: insights into engineering thermostable enzymes for CO2 sequestration. Díaz-Torres NA, Mahon BP, Boone CD, Pinard MA, Tu C, Ng R, Agbandje-McKenna M, Silverman D, Scott K, McKenna R. Acta Crystallogr D Biol Crystallogr 71 1745-1756 (2015)
  3. Identification and characterization of a novel zebrafish (Danio rerio) pentraxin-carbonic anhydrase. Patrikainen MS, Tolvanen MEE, Aspatwar A, Barker HR, Ortutay C, Jänis J, Laitaoja M, Hytönen VP, Azizi L, Manandhar P, Jáger E, Vullo D, Kukkurainen S, Hilvo M, Supuran CT, Parkkila S. PeerJ 5 e4128 (2017)
  4. Acipimox inhibits human carbonic anhydrases. Mori M, Supuran CT. J Enzyme Inhib Med Chem 37 672-679 (2022)
  5. Isoform-Selective Enzyme Inhibitors by Exploring Pocket Size According to the Lock-and-Key Principle. Dudutienė V, Zubrienė A, Kairys V, Smirnov A, Smirnovienė J, Leitans J, Kazaks A, Tars K, Manakova L, Gražulis S, Matulis D. Biophys J 119 1513-1524 (2020)
  6. Engineered Carbonic Anhydrase VI-Mimic Enzyme Switched the Structure and Affinities of Inhibitors. Kazokaitė J, Kairys V, Smirnovienė J, Smirnov A, Manakova E, Tolvanen M, Parkkila S, Matulis D. Sci Rep 9 12710 (2019)
  7. The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins. Chakraborty S, Rendón-Ramírez A, Ásgeirsson B, Dutta M, Ghosh AS, Oda M, Venkatramani R, Rao BJ, Dandekar AM, Goñi FM. F1000Res 2 286 (2013)
  8. A reverse vaccinology approach on transmembrane carbonic anhydrases from Plasmodium species as vaccine candidates for malaria prevention. Zolfaghari Emameh R, Barker HR, Turpeinen H, Parkkila S, Hytönen VP. Malar J 21 189 (2022)
  9. Biochemical and Biophysical Characterization of Carbonic Anhydrase VI from Human Milk and Saliva. Yrjänäinen A, Patrikainen MS, Azizi L, Tolvanen MEE, Laitaoja M, Jänis J, Hytönen VP, Nocentini A, Supuran CT, Parkkila S. Protein J 41 489-503 (2022)


Reviews citing this publication (12)

  1. Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one. Supuran CT, Alterio V, Di Fiore A, D' Ambrosio K, Carta F, Monti SM, De Simone G. Med Res Rev 38 1799-1836 (2018)
  2. Structural annotation of human carbonic anhydrases. Aggarwal M, Boone CD, Kondeti B, McKenna R. J Enzyme Inhib Med Chem 28 267-277 (2013)
  3. Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment. Angeli A, Carta F, Nocentini A, Winum JY, Zalubovskis R, Akdemir A, Onnis V, Eldehna WM, Capasso C, Simone G, Monti SM, Carradori S, Donald WA, Dedhar S, Supuran CT. Metabolites 10 E412 (2020)
  4. Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase. Nocentini A, Angeli A, Carta F, Winum JY, Zalubovskis R, Carradori S, Capasso C, Donald WA, Supuran CT. J Enzyme Inhib Med Chem 36 561-580 (2021)
  5. Probing the surface of human carbonic anhydrase for clues towards the design of isoform specific inhibitors. Pinard MA, Mahon B, McKenna R. Biomed Res Int 2015 453543 (2015)
  6. Carbonic anhydrase inhibitors: a review on the progress of patent literature (2011-2016). Lomelino C, McKenna R. Expert Opin Ther Pat 26 947-956 (2016)
  7. Insights into the role of reactive sulfhydryl groups of Carbonic Anhydrase III and VII during oxidative damage. Monti DM, De Simone G, Langella E, Supuran CT, Di Fiore A, Monti SM. J Enzyme Inhib Med Chem 32 5-12 (2017)
  8. Thermostable Carbonic Anhydrases in Biotechnological Applications. Di Fiore A, Alterio V, Monti SM, De Simone G, D'Ambrosio K. Int J Mol Sci 16 15456-15480 (2015)
  9. Thermodynamic, kinetic, and structural parameterization of human carbonic anhydrase interactions toward enhanced inhibitor design. Linkuvienė V, Zubrienė A, Manakova E, Petrauskas V, Baranauskienė L, Zakšauskas A, Smirnov A, Gražulis S, Ladbury JE, Matulis D. Q Rev Biophys 51 e10 (2018)
  10. Human carbonic anhydrases and post-translational modifications: a hidden world possibly affecting protein properties and functions. Di Fiore A, Supuran CT, Scaloni A, De Simone G. J Enzyme Inhib Med Chem 35 1450-1461 (2020)
  11. A matter of structure: structural comparison of fungal carbonic anhydrases. Lehneck R, Pöggeler S. Appl Microbiol Biotechnol 98 8433-8441 (2014)
  12. Post-translational modifications in tumor-associated carbonic anhydrases. Di Fiore A, Supuran CT, Scaloni A, De Simone G. Amino Acids 54 543-558 (2022)

Articles citing this publication (11)

  1. Two adjacent inversions maintain genomic differentiation between migratory and stationary ecotypes of Atlantic cod. Kirubakaran TG, Grove H, Kent MP, Sandve SR, Baranski M, Nome T, De Rosa MC, Righino B, Johansen T, Otterå H, Sonesson A, Lien S, Andersen Ø. Mol Ecol 25 2130-2143 (2016)
  2. X-ray structure of the first `extremo-α-carbonic anhydrase', a dimeric enzyme from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1. Di Fiore A, Capasso C, De Luca V, Monti SM, Carginale V, Supuran CT, Scozzafava A, Pedone C, Rossi M, De Simone G. Acta Crystallogr D Biol Crystallogr 69 1150-1159 (2013)
  3. Crystal structure of the most catalytically effective carbonic anhydrase enzyme known, SazCA from the thermophilic bacterium Sulfurihydrogenibium azorense. De Simone G, Monti SM, Alterio V, Buonanno M, De Luca V, Rossi M, Carginale V, Supuran CT, Capasso C, Di Fiore A. Bioorg Med Chem Lett 25 2002-2006 (2015)
  4. Crystal structures of two tetrameric β-carbonic anhydrases from the filamentous ascomycete Sordaria macrospora. Lehneck R, Neumann P, Vullo D, Elleuche S, Supuran CT, Ficner R, Pöggeler S. FEBS J 281 1759-1772 (2014)
  5. The structural comparison between membrane-associated human carbonic anhydrases provides insights into drug design of selective inhibitors. Alterio V, Pan P, Parkkila S, Buonanno M, Supuran CT, Monti SM, De Simone G. Biopolymers 101 769-778 (2014)
  6. Biochemical characterization of the native α-carbonic anhydrase purified from the mantle of the Mediterranean mussel, Mytilus galloprovincialis. Perfetto R, Del Prete S, Vullo D, Sansone G, Barone C, Rossi M, Supuran CT, Capasso C. J Enzyme Inhib Med Chem 32 632-639 (2017)
  7. Intrinsic binding of 4-substituted-2,3,5,6-tetrafluorobenezenesulfonamides to native and recombinant human carbonic anhydrase VI. Kazokaitė J, Milinavičiūtė G, Smirnovienė J, Matulienė J, Matulis D. FEBS J 282 972-983 (2015)
  8. Cloning, purification and preliminary crystallographic analysis of the complex of Helicobacter pylori α-carbonic anhydrase with acetazolamide. Modak JK, Revitt-Mills SA, Roujeinikova A. Acta Crystallogr Sect F Struct Biol Cryst Commun 69 1252-1255 (2013)
  9. Exploration of the residues modulating the catalytic features of human carbonic anhydrase XIII by a site-specific mutagenesis approach. De Simone G, Di Fiore A, Truppo E, Langella E, Vullo D, Supuran CT, Monti SM. J Enzyme Inhib Med Chem 34 1506-1510 (2019)
  10. Crystal Structure of β-Carbonic Anhydrase CafA from the Fungal Pathogen Aspergillus fumigatus. Kim S, Yeon J, Sung J, Jin MS. Mol Cells 43 831-840 (2020)
  11. A novel proteochemometrics model for predicting the inhibition of nine carbonic anhydrase isoforms based on supervised Laplacian score and k-nearest neighbour regression. Nazarshodeh E, Sheikhpour R, Gharaghani S, Sarram MA. SAR QSAR Environ Res 29 419-437 (2018)


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