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Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases

Mac Sweeney A, Parrado SG, Vinzenz D, Bernardi A, Hein A, Bodendorf U, Erbel P, Logel C, Gerhartz B
To be published
Cited: 32 times

Reviews - 3edg mentioned but not cited (1)

  1. Architecture and function of metallopeptidase catalytic domains. Cerdà-Costa N, Gomis-Rüth FX. Protein Sci 23 123-144 (2014)

Articles - 3edg mentioned but not cited (5)

  1. Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates. Becker-Pauly C, Barré O, Schilling O, Auf dem Keller U, Ohler A, Broder C, Schütte A, Kappelhoff R, Stöcker W, Overall CM. Mol. Cell Proteomics 10 M111.009233 (2011)
  2. Druggability of Coronary Artery Disease Risk Loci. Tragante V, Hemerich D, Alshabeeb M, Brænne I, Lempiäinen H, Patel RS, den Ruijter HM, Barnes MR, Moore JH, Schunkert H, Erdmann J, Asselbergs FW. Circ Genom Precis Med 11 e001977 (2018)
  3. Crystallization and preliminary X-ray analysis of ZHE1, a hatching enzyme from the zebrafish Danio rerio. Okada A, Nagata K, Sano K, Yasumasu S, Kubota K, Ohtsuka J, Iuchi I, Tanokura M. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65 1018-1020 (2009)
  4. A Primary Evaluation of Potential Small-Molecule Inhibitors of the Astacin Metalloproteinase Ovastacin, a Novel Drug Target in Female Infertility Treatment. Körschgen H, Jäger C, Tan K, Buchholz M, Stöcker W, Ramsbeck D. ChemMedChem 15 1499-1504 (2020)
  5. Structure and Dynamics of Meprin β in Complex with a Hydroxamate-Based Inhibitor. Linnert M, Fritz C, Jäger C, Schlenzig D, Ramsbeck D, Kleinschmidt M, Wermann M, Demuth HU, Parthier C, Schilling S. Int J Mol Sci 22 5651 (2021)


Reviews citing this publication (6)

  1. Bone morphogenetic protein and growth differentiation factor cytokine families and their protein antagonists. Rider CC, Mulloy B. Biochem. J. 429 1-12 (2010)
  2. BMP-1/tolloid-like proteinases synchronize matrix assembly with growth factor activation to promote morphogenesis and tissue remodeling. Vadon-Le Goff S, Hulmes DJ, Moali C. Matrix Biol. 44-46 14-23 (2015)
  3. Metalloproteinases in Drosophila to humans that are central players in developmental processes. Muir A, Greenspan DS. J. Biol. Chem. 286 41905-41911 (2011)
  4. Fine-tuned shuttles for bone morphogenetic proteins. Wharton KA, Serpe M. Curr. Opin. Genet. Dev. 23 374-384 (2013)
  5. Roles of bone morphogenetic protein signaling in osteosarcoma. Nguyen A, Scott MA, Dry SM, James AW. Int Orthop 38 2313-2322 (2014)
  6. Mammalian tolloid proteinases: role in growth factor signalling. Troilo H, Bayley CP, Barrett AL, Lockhart-Cairns MP, Jowitt TA, Baldock C. FEBS Lett. 590 2398-2407 (2016)

Articles citing this publication (20)

  1. Shaping BMP morphogen gradients through enzyme-substrate interactions. Peluso CE, Umulis D, Kim YJ, O'Connor MB, Serpe M. Dev. Cell 21 375-383 (2011)
  2. The origin of bmp16, a novel Bmp2/4 relative, retained in teleost fish genomes. Feiner N, Begemann G, Renz AJ, Meyer A, Kuraku S. BMC Evol. Biol. 9 277 (2009)
  3. Sizzled is unique among secreted frizzled-related proteins for its ability to specifically inhibit bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases. Bijakowski C, Vadon-Le Goff S, Delolme F, Bourhis JM, Lécorché P, Ruggiero F, Becker-Pauly C, Yiallouros I, Stöcker W, Dive V, Hulmes DJ, Moali C. J. Biol. Chem. 287 33581-33593 (2012)
  4. Crystal structure of zebrafish hatching enzyme 1 from the zebrafish Danio rerio. Okada A, Sano K, Nagata K, Yasumasu S, Ohtsuka J, Yamamura A, Kubota K, Iuchi I, Tanokura M. J. Mol. Biol. 402 865-878 (2010)
  5. Prodomain removal enables neto to stabilize glutamate receptors at the Drosophila neuromuscular junction. Kim YJ, Igiesuorobo O, Ramos CI, Bao H, Zhang B, Serpe M. PLoS Genet. 11 e1004988 (2015)
  6. Synthetic enzyme-substrate tethering obviates the Tolloid-ECM interaction during Drosophila BMP gradient formation. Winstanley J, Sawala A, Baldock C, Ashe HL. Elife 4 (2015)
  7. Broad Analysis of Vicinal Disulfides: Occurrences, Conformations with Cis or with Trans Peptides, and Functional Roles Including Sugar Binding. Richardson JS, Videau LL, Williams CJ, Richardson DC. J. Mol. Biol. 429 1321-1335 (2017)
  8. Procollagen C-proteinase enhancer-1 (PCPE-1), a potential biomarker and therapeutic target for fibrosis. Lagoutte P, Bettler E, Vadon-Le Goff S, Moali C. Matrix Biol Plus 11 100062 (2021)
  9. Mammalian plasma fetuin-B is a selective inhibitor of ovastacin and meprin metalloproteinases. Karmilin K, Schmitz C, Kuske M, Körschgen H, Olf M, Meyer K, Hildebrand A, Felten M, Fridrich S, Yiallouros I, Becker-Pauly C, Weiskirchen R, Jahnen-Dechent W, Floehr J, Stöcker W. Sci Rep 9 546 (2019)
  10. Structural Basis for the Acceleration of Procollagen Processing by Procollagen C-Proteinase Enhancer-1. Pulido D, Sharma U, Vadon-Le Goff S, Hussain SA, Cordes S, Mariano N, Bettler E, Moali C, Aghajari N, Hohenester E, Hulmes DJS. Structure 26 1384-1392.e3 (2018)
  11. Myroilysin Is a New Bacterial Member of the M12A Family of Metzincin Metallopeptidases and Is Activated by a Cysteine Switch Mechanism. Xu D, Zhou J, Lou X, He J, Ran T, Wang W. J. Biol. Chem. 292 5195-5206 (2017)
  12. BMP1 is not required for lung fibrosis in mice. Ma HY, N'Diaye EN, Caplazi P, Huang Z, Arlantico A, Jeet S, Wong A, Brightbill HD, Li Q, Wong WR, Sandoval W, Tam L, Newman R, Roose-Girma M, Ding N. Sci Rep 12 5466 (2022)
  13. Characterization of tolloid-mediated cleavage of the GDF8 procomplex. McCoy JC, Goebel EJ, Thompson TB. Biochem J 478 1733-1747 (2021)
  14. Dynamics of the secreted frizzled related protein Sizzled and potential implications for binding to bone morphogenetic protein-1 (BMP-1). Sharma U, Vadon-Le Goff S, Harlos K, Zhao Y, Mariano N, Bijakowski C, Bourhis JM, Moali C, Hulmes DJS, Aghajari N. Sci Rep 12 14850 (2022)
  15. Influence of WFIKKN1 on BMP1-mediated activation of latent myostatin. Szláma G, Vásárhelyi V, Trexler M, Patthy L. FEBS J. 283 4515-4527 (2016)
  16. Inhibitors of BMP-1/tolloid-like proteinases: efficacy, selectivity and cellular toxicity. Talantikite M, Lécorché P, Beau F, Damour O, Becker-Pauly C, Ho WB, Dive V, Vadon-Le Goff S, Moali C. FEBS Open Bio 8 2011-2021 (2018)
  17. Meprin β and BMP-1 are differentially regulated by CaCl2. Schneppenheim J, Scharfenberg F, Lucius R, Becker-Pauly C, Arnold P. Cell Calcium 65 8-13 (2017)
  18. Regulating the cell shift of endothelial cell-like myofibroblasts in pulmonary fibrosis. Wu X, Zhang D, Qiao X, Zhang L, Cai X, Ji J, Ma JA, Zhao Y, Belperio JA, Boström KI, Yao Y. Eur Respir J 61 2201799 (2023)
  19. Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1. Kallander LS, Washburn D, Hilfiker MA, Eidam HS, Lawhorn BG, Prendergast J, Fox R, Dowdell S, Manns S, Hoang T, Zhao S, Ye G, Hammond M, Holt DA, Roethke T, Hong X, Reid RA, Gampe R, Zhang H, Diaz E, Rendina AR, Quinn AM, Willette B. ACS Med Chem Lett 9 736-740 (2018)
  20. Tolloid-Like 1 Negatively Regulates Hepatic Differentiation of Human Induced Pluripotent Stem Cells Through Transforming Growth Factor Beta Signaling. Kiso A, Toba Y, Tsutsumi S, Deguchi S, Igai K, Koshino S, Tanaka Y, Takayama K, Mizuguchi H. Hepatol Commun 4 255-267 (2020)


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