› › Function and Biology

Crystal structure of a papain-like cysteine protease Ervatamin-A complexed with irreversible inhibitor E-64

Source organism: Tabernaemontana divaricata
Biochemical function: cysteine-type peptidase activity
Biological process: proteolysis involved in protein catabolic process
Cellular component: lysosome

Quick links

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00112
Domain description: Papain family cysteine protease
Occurring in:
  1. Ervatamin-A
The deposited structure of PDB entry 3bcn contains 2 copies of Pfam domain PF00112 (Papain family cysteine protease) in Ervatamin-A. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000668
Domain description: Peptidase C1A, papain C-terminal
Occurring in:
  1. Ervatamin-A
IPR025660
Domain description: Cysteine peptidase, histidine active site
Occurring in:
  1. Ervatamin-A
IPR000169
Domain description: Cysteine peptidase, cysteine active site
Occurring in:
  1. Ervatamin-A
IPR013128
Domain description: Peptidase C1A
Occurring in:
  1. Ervatamin-A
IPR039417
Domain description: Papain-like cysteine endopeptidase
Occurring in:
  1. Ervatamin-A
IPR038765
Domain description: Papain-like cysteine peptidase superfamily
Occurring in:
  1. Ervatamin-A

Structure domain

CATH CATH domain
3.90.70.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Cathepsin B; Chain A
Homology: Cysteine proteinases
Occurring in:
  1. Ervatamin-A
The deposited structure of PDB entry 3bcn contains 2 copies of CATH domain 3.90.70.10 (Cathepsin B; Chain A) in Ervatamin-A. Showing 1 copy in chain A.

Quick links