› 3trd

X-ray diffraction
1.5Å resolution

Structure of an alpha-beta serine hydrolase homologue from Coxiella burnetii

Released:
DOI: 10.2210/pdb3trd/pdb
PDB entry 3trd coloured by chain, front view.
PDB entry 3trd coloured by chain, side view.
PDB entry 3trd coloured by chain, top view.
Source organism: Coxiella burnetii
Primary publication:
Structural genomics for drug design against the pathogen Coxiella burnetii.
Franklin MC, Cheung J, Rudolph MJ, Burshteyn F, Cassidy M, Gary E, Hillerich B, Yao ZK, Carlier PR, Totrov M, Love JD
Proteins 83 2124-36 (2015)
PMID: 26033498

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182901 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
AB hydrolase-1 domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 208 amino acids
Theoretical weight: 23.14 KDa
Source organism: Coxiella burnetii
Expression system: Escherichia coli
UniProt:
  • Canonical: Q83AV9 (Residues: 1-205; Coverage: 100%)
Gene name: CBU_1769
Sequence domains: alpha/beta hydrolase fold
Structure domains: alpha/beta hydrolase

Ligands and Environments

3 bound ligands:
Ligand ACT 2 x ACT
Ligand NA 2 x NA
Ligand PO4 2 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: P212121
Unit cell:
a: 49.861Å b: 55.905Å c: 62.513Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.168 0.166 0.2
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Laccases of prokaryotic origin: enzymes at the interface of protein science and protein technology.
Martins et al. (2015)
4 more

4 mentions without citation

Autophagy and endosomal trafficking inhibition by Vibrio cholerae MARTX toxin phosphatidylinositol-3-phosphate-specific phospholipase A1 activity.
Agarwal et al. (2015)
3 more