PDBe 3eta

X-ray diffraction
2.6Å resolution

Kinase domain of insulin receptor complexed with a pyrrolo pyridine inhibitor

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin receptor subunit beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 317 amino acids
Theoretical weight: 36.16 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P06213 (Residues: 1017-1322; Coverage: 23%)
Gene name: INSR
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 89.105Å b: 94.751Å c: 129.858Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.201 0.232
Expression system: Spodoptera frugiperda