PDBe 2yu7

Solution NMR

Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A

Released:
Source organism: Homo sapiens
Entry authors: Kasai T, Koshiba S, Inoue M, Kigawa T, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. 
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
NKG2-A/NKG2-B type II integral membrane protein Chain: B
Molecule details ›
Chain: B
Length: 15 amino acids
Theoretical weight: 1.83 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P26715 (Residues: 33-47; Coverage: 6%)
Gene names: KLRC1, NKG2A
Tyrosine-protein phosphatase non-receptor type 6 Chain: A
Molecule details ›
Chain: A
Length: 118 amino acids
Theoretical weight: 12.61 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P29350 (Residues: 110-214; Coverage: 18%)
Gene names: HCP, PTP1C, PTPN6
Sequence domains: SH2 domain
Structure domains: SHC Adaptor Protein

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics, restrainted molecular dynamics
Expression system: Not provided