PDBe 2xs6

X-ray diffraction
2.09Å resolution

CRYSTAL STRUCTURE OF THE RHOGAP DOMAIN OF HUMAN PIK3R2

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 3-kinase regulatory subunit beta Chain: A
Molecule details ›
Chain: A
Length: 214 amino acids
Theoretical weight: 22.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O00459 (Residues: 108-298; Coverage: 26%)
Gene name: PIK3R2
Sequence domains: RhoGAP domain
Structure domains: GTPase -GAP domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: C2
Unit cell:
a: 94.661Å b: 34.354Å c: 71.317Å
α: 90° β: 130.88° γ: 90°
R-values:
R R work R free
0.194 0.191 0.24
Expression system: Escherichia coli BL21(DE3)