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HMGB1-facilitated p53 DNA binding occurs via HMG-Box/p53 transactivation domain interaction, regulated by the acidic tail.

Rowell JP, Simpson KL, Stott K, Watson M, Thomas JO
Structure 20 2014-24 (2012)
Cited: 87 times
EuropePMC logo PMID: 23063560

Abstract

Facilitated binding of p53 to DNA by high mobility group B1 (HMGB1) may involve interaction between the N-terminal region of p53 and the high mobility group (HMG) boxes, as well as HMG-induced bending of the DNA. Intramolecular shielding of the boxes by the HMGB1 acidic tail results in an unstable complex with p53 until the tail is truncated to half its length, at which point the A box, proposed to be the preferred binding site for p53(1-93), is exposed, leaving the B box to bind and bend DNA. The A box interacts with residues 38-61 (TAD2) of the p53 transactivation domain. Residues 19-26 (TAD1) bind weakly, but only in the context of p53(1-93) and not as a free TAD1 peptide. We have solved the structure of the A-box/p53(1-93) complex by nuclear magnetic resonance spectroscopy. The incipient amphipathic helix in TAD2 recognizes the concave DNA-binding face of the A box and may be acting as a single-stranded DNA mimic.

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  15. High Mobility Group B Proteins, Their Partners, and Other Redox Sensors in Ovarian and Prostate Cancer. Barreiro-Alonso A, Lamas-Maceiras M, Rodríguez-Belmonte E, Vizoso-Vázquez Á, Quindós M, Cerdán ME. Oxid Med Cell Longev 2016 5845061 (2016)
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  20. Functional Diversity of Non-Histone Chromosomal Protein HmgB1. Chikhirzhina E, Starkova T, Beljajev A, Polyanichko A, Tomilin A. Int J Mol Sci 21 E7948 (2020)
  21. Asparaginase treatment side-effects may be due to genes with homopolymeric Asn codons (Review-Hypothesis). Banerji J. Int J Mol Med 36 607-626 (2015)
  22. Targeting HMGB1: An available Therapeutic Strategy for Breast Cancer Therapy. Dong H, Zhang L, Liu S. Int J Biol Sci 18 3421-3434 (2022)
  23. RAGE Inhibitors for Targeted Therapy of Cancer: A Comprehensive Review. Faruqui T, Khan MS, Akhter Y, Khan S, Rafi Z, Saeed M, Han I, Choi EH, Yadav DK. Int J Mol Sci 24 266 (2022)
  24. Structure-specific nucleic acid recognition by L-motifs and their diverse roles in expression and regulation of the genome. Thapar R. Biochim Biophys Acta 1849 677-687 (2015)
  25. Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer's disease: Evidence from clinical and preclinical studies. Gaikwad S, Senapati S, Haque MA, Kayed R. Alzheimers Dement 20 709-727 (2024)
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  27. Thanksgiving to Yeast, the HMGB Proteins History from Yeast to Cancer. Lamas-Maceiras M, Vizoso-Vázquez Á, Barreiro-Alonso A, Cámara-Quílez M, Cerdán ME. Microorganisms 11 993 (2023)

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  2. Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein. Krois AS, Ferreon JC, Martinez-Yamout MA, Dyson HJ, Wright PE. Proc Natl Acad Sci U S A 113 E1853-62 (2016)
  3. Quality and bias of protein disorder predictors. Nielsen JT, Mulder FAA. Sci Rep 9 5137 (2019)
  4. Characterization of the p300 Taz2-p53 TAD2 complex and comparison with the p300 Taz2-p53 TAD1 complex. Miller Jenkins LM, Feng H, Durell SR, Tagad HD, Mazur SJ, Tropea JE, Bai Y, Appella E. Biochemistry 54 2001-2010 (2015)
  5. The p53 tetramer shows an induced-fit interaction of the C-terminal domain with the DNA-binding domain. D'Abramo M, Bešker N, Desideri A, Levine AJ, Melino G, Chillemi G. Oncogene 35 3272-3281 (2016)
  6. ODiNPred: comprehensive prediction of protein order and disorder. Dass R, Mulder FAA, Nielsen JT. Sci Rep 10 14780 (2020)
  7. High-mobility group box 1 promotes extracellular matrix synthesis and wound repair in human bronchial epithelial cells. Ojo OO, Ryu MH, Jha A, Unruh H, Halayko AJ. Am J Physiol Lung Cell Mol Physiol 309 L1354-66 (2015)
  8. Sequence-based prediction of protein binding mode landscapes. Horvath A, Miskei M, Ambrus V, Vendruscolo M, Fuxreiter M. PLoS Comput Biol 16 e1007864 (2020)
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  10. ETV4 and AP1 Transcription Factors Form Multivalent Interactions with three Sites on the MED25 Activator-Interacting Domain. Currie SL, Doane JJ, Evans KS, Bhachech N, Madison BJ, Lau DKW, McIntosh LP, Skalicky JJ, Clark KA, Graves BJ. J Mol Biol 429 2975-2995 (2017)
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  15. TOX4 and NOVA1 proteins are partners of the LEDGF PWWP domain and affect HIV-1 replication. Morchikh M, Naughtin M, Di Nunzio F, Xavier J, Charneau P, Jacob Y, Lavigne M. PLoS One 8 e81217 (2013)
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  17. Regulation of Neurogenesis in Mouse Brain by HMGB1. Zhao X, Rouhiainen A, Li Z, Guo S, Rauvala H. Cells 9 E1714 (2020)
  18. Single-molecule analysis of RAG-mediated V(D)J DNA cleavage. Lovely GA, Brewster RC, Schatz DG, Baltimore D, Phillips R. Proc Natl Acad Sci U S A 112 E1715-23 (2015)
  19. HMGB1 bound to cisplatin-DNA adducts undergoes extensive acetylation and phosphorylation in vivo. He Y, Ding Y, Wang D, Zhang W, Chen W, Liu X, Qin W, Qian X, Chen H, Guo Z. Chem Sci 6 2074-2078 (2015)
  20. Characterization of the structural ensembles of p53 TAD2 by molecular dynamics simulations with different force fields. Ouyang Y, Zhao L, Zhang Z. Phys Chem Chem Phys 20 8676-8684 (2018)
  21. NMR characterization of solvent accessibility and transient structure in intrinsically disordered proteins. Hartlmüller C, Spreitzer E, Göbl C, Falsone F, Madl T. J Biomol NMR 73 305-317 (2019)
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  23. Upregulation of heat shock protein 70 and the differential protein expression induced by tumor necrosis factor-alpha enhances migration and inhibits apoptosis of hepatocellular carcinoma cell HepG2. Huang BP, Lin CS, Wang CJ, Kao SH. Int J Med Sci 14 284-293 (2017)
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  25. The DNA chaperone HMGB1 potentiates the transcriptional activity of Rel1A in the mosquito Aedes aegypti. de Mendonça Amarante A, Jupatanakul N, de Abreu da Silva IC, Carneiro VC, Vicentino ARR, Dimopolous G, Talyuli OAC, Fantappié MR. Insect Biochem Mol Biol 80 32-41 (2017)
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  40. The acidic intrinsically disordered region of the inflammatory mediator HMGB1 mediates fuzzy interactions with CXCL12. Mantonico MV, De Leo F, Quilici G, Colley LS, De Marchis F, Crippa M, Mezzapelle R, Schulte T, Zucchelli C, Pastorello C, Carmeno C, Caprioglio F, Ricagno S, Giachin G, Ghitti M, Bianchi ME, Musco G. Nat Commun 15 1201 (2024)


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