PDBe 2w51

X-ray diffraction
2.8Å resolution

Human mesencephalic astrocyte-derived neurotrophic factor (MANF)

Released:

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mesencephalic astrocyte-derived neurotrophic factor Chain: A
Molecule details ›
Chain: A
Length: 158 amino acids
Theoretical weight: 18.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P55145 (Residues: 25-182; Coverage: 100%)
Gene names: ARMET, ARP, MANF
Sequence domains: Degradation arginine-rich protein for mis-folding
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P61
Unit cell:
a: 96.5Å b: 96.5Å c: 35.05Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.281 0.28 0.305
Expression system: Escherichia coli