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Crystal structure of the human protein tyrosine phosphatase PTPN5 (STEP, striatum enriched enriched Phosphatase)

X-ray diffraction
2.05Å resolution
PDB entry 2bij coloured by chain, front view.
PDB entry 2bij coloured by chain, side view.
PDB entry 2bij coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein phosphatase non-receptor type 5
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Multimeric state: monomeric
Accessible surface area: 12611.59 Å2
Buried surface area: 197.14 Å2
Dissociation area: 98.57 Å2
Dissociation energy (ΔGdiss): 15.16 kcal/mol
Dissociation entropy (TΔSdiss): 0.6 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-157113

Macromolecules

Tyrosine-protein phosphatase non-receptor type 5
Chain: A
Length: 305 amino acids
Theoretical weight: 35.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P54829 (Residues: 277-563; Coverage: 51%)
Gene name: PTPN5
Pfam: Protein-tyrosine phosphatase
InterPro:
CATH: Protein tyrosine phosphatase superfamily
Tyrosine-protein phosphatase non-receptor type 5 in PDB entry 2bij, assembly 1, front view.
Tyrosine-protein phosphatase non-receptor type 5 in PDB entry 2bij, assembly 1, side view.
Tyrosine-protein phosphatase non-receptor type 5 in PDB entry 2bij, assembly 1, top view.
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