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Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins.

Gentry HR, Singer AU, Betts L, Yang C, Ferrara JD, Sondek J, Parise LV
J Biol Chem 280 8407-15 (2005)
Cited: 67 times
EuropePMC logo PMID: 15574431

Abstract

CIB1 (CIB) is an EF-hand-containing protein that binds multiple effector proteins, including the platelet alphaIIbbeta3 integrin and several serine/threonine kinases and potentially modulates their function. The crystal structure for Ca(2+)-bound CIB1 has been determined at 2.0 A resolution and reveals a compact alpha-helical protein containing four EF-hands, the last two of which bind calcium ions in the standard fashion seen in many other EF-hand proteins. CIB1 shares high structural similarity with calcineurin B and the neuronal calcium sensor (NCS) family of EF-hand-containing proteins. Most importantly, like calcineurin B and NCS proteins, which possess a large hydrophobic pocket necessary for ligand binding, CIB1 contains a hydrophobic pocket that has been implicated in ligand binding by previous mutational analysis. However, unlike several NCS proteins, Ca(2+)-bound CIB1 is largely monomeric whether bound to a relevant peptide ligand or ligand-free. Differences in structure, oligomeric state, and phylogeny define a new family of CIB1-related proteins that extends from arthropods to humans.

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  1. Resolving the topological enigma in Ca2+ signaling by cyclic ADP-ribose and NAADP. Lee HC, Zhao YJ. J Biol Chem 294 19831-19843 (2019)
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Articles - 1xo5 mentioned but not cited (13)

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Articles citing this publication (39)

  1. Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48. Riazuddin S, Belyantseva IA, Giese AP, Lee K, Indzhykulian AA, Nandamuri SP, Yousaf R, Sinha GP, Lee S, Terrell D, Hegde RS, Ali RA, Anwar S, Andrade-Elizondo PB, Sirmaci A, Parise LV, Basit S, Wali A, Ayub M, Ansar M, Ahmad W, Khan SN, Akram J, Tekin M, Riazuddin S, Cook T, Buschbeck EK, Frolenkov GI, Leal SM, Friedman TB, Ahmed ZM. Nat Genet 44 1265-1271 (2012)
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  3. Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1. Jarman KE, Moretti PA, Zebol JR, Pitson SM. J Biol Chem 285 483-492 (2010)
  4. CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells. Giese APJ, Tang YQ, Sinha GP, Bowl MR, Goldring AC, Parker A, Freeman MJ, Brown SDM, Riazuddin S, Fettiplace R, Schafer WR, Frolenkov GI, Ahmed ZM. Nat Commun 8 43 (2017)
  5. Loss of CIB2 Causes Profound Hearing Loss and Abolishes Mechanoelectrical Transduction in Mice. Wang Y, Li J, Yao X, Li W, Du H, Tang M, Xiong W, Chai R, Xu Z. Front Mol Neurosci 10 401 (2017)
  6. CIB1 is a regulator of pathological cardiac hypertrophy. Heineke J, Auger-Messier M, Correll RN, Xu J, Benard MJ, Yuan W, Drexler H, Parise LV, Molkentin JD. Nat Med 16 872-879 (2010)
  7. CIB1 is an endogenous inhibitor of agonist-induced integrin alphaIIbbeta3 activation. Yuan W, Leisner TM, McFadden AW, Wang Z, Larson MK, Clark S, Boudignon-Proudhon C, Lam SC, Parise LV. J Cell Biol 172 169-175 (2006)
  8. CIB1 is essential for mouse spermatogenesis. Yuan W, Leisner TM, McFadden AW, Clark S, Hiller S, Maeda N, O'Brien DA, Parise LV. Mol Cell Biol 26 8507-8514 (2006)
  9. Essential role of CIB1 in regulating PAK1 activation and cell migration. Leisner TM, Liu M, Jaffer ZM, Chernoff J, Parise LV. J Cell Biol 170 465-476 (2005)
  10. CIB1 functions as a Ca(2+)-sensitive modulator of stress-induced signaling by targeting ASK1. Yoon KW, Cho JH, Lee JK, Kang YH, Chae JS, Kim YM, Kim J, Kim EK, Kim SE, Baik JH, Naik UP, Cho SG, Choi EJ. Proc Natl Acad Sci U S A 106 17389-17394 (2009)
  11. Crystal structure of CHP2 complexed with NHE1-cytosolic region and an implication for pH regulation. Ammar YB, Takeda S, Hisamitsu T, Mori H, Wakabayashi S. EMBO J 25 2315-2325 (2006)
  12. Structural insights into Ca2+-dependent regulation of inositol 1,4,5-trisphosphate receptors by CaBP1. Li C, Chan J, Haeseleer F, Mikoshiba K, Palczewski K, Ikura M, Ames JB. J Biol Chem 284 2472-2481 (2009)
  13. Cib2 binds integrin alpha7Bbeta1D and is reduced in laminin alpha2 chain-deficient muscular dystrophy. Häger M, Bigotti MG, Meszaros R, Carmignac V, Holmberg J, Allamand V, Akerlund M, Kalamajski S, Brancaccio A, Mayer U, Durbeej M. J Biol Chem 283 24760-24769 (2008)
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  18. Biochemical characterization and expression analysis of a novel EF-hand Ca2+ binding protein calmyrin2 (Cib2) in brain indicates its function in NMDA receptor mediated Ca2+ signaling. Blazejczyk M, Sobczak A, Debowska K, Wisniewska MB, Kirilenko A, Pikula S, Jaworski J, Kuznicki J, Wojda U. Arch Biochem Biophys 487 66-78 (2009)
  19. CIB1 synergizes with EphrinA2 to regulate Kaposi's sarcoma-associated herpesvirus macropinocytic entry in human microvascular dermal endothelial cells. Bandyopadhyay C, Valiya-Veettil M, Dutta D, Chakraborty S, Chandran B. PLoS Pathog 10 e1003941 (2014)
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  24. Identification of novel integrin binding partners for calcium and integrin binding protein 1 (CIB1): structural and thermodynamic basis of CIB1 promiscuity. Freeman TC, Black JL, Bray HG, Dagliyan O, Wu YI, Tripathy A, Dokholyan NV, Leisner TM, Parise LV. Biochemistry 52 7082-7090 (2013)
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  26. Crystal-structure and biochemical characterization of recombinant human calcyphosine delineates a novel EF-hand-containing protein family. Dong H, Li X, Lou Z, Xu X, Su D, Zhou X, Zhou W, Bartlam M, Rao Z. J Mol Biol 383 455-464 (2008)
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  28. Regulation of IP(3)R Channel Gating by Ca(2+) and Ca(2+) Binding Proteins. Foskett JK, Daniel Mak DO. Curr Top Membr 66 235-272 (2010)
  29. A gene therapeutic approach to inhibit calcium and integrin binding protein 1 ameliorates maladaptive remodelling in pressure overload. Grund A, Szaroszyk M, Döppner JK, Malek Mohammadi M, Kattih B, Korf-Klingebiel M, Gigina A, Scherr M, Kensah G, Jara-Avaca M, Gruh I, Martin U, Wollert KC, Gohla A, Katus HA, Müller OJ, Bauersachs J, Heineke J. Cardiovasc Res 115 71-82 (2019)
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  31. CIB4 is essential for the haploid phase of spermatogenesis in mice†. Xu Z, Miyata H, Kaneda Y, Castaneda JM, Lu Y, Morohoshi A, Yu Z, Matzuk MM, Ikawa M. Biol Reprod 103 235-243 (2020)
  32. Discovery and Development of Cyclic Peptide Inhibitors of CIB1. Haberman VA, Fleming SR, Leisner TM, Puhl AC, Feng E, Xie L, Chen X, Goto Y, Suga H, Parise LV, Kireev D, Pearce KH, Bowers AA. ACS Med Chem Lett 12 1832-1839 (2021)
  33. Integrated multiomics approach identifies calcium and integrin-binding protein-2 as a novel gene for pulse wave velocity. Mangino M, Cecelja M, Menni C, Tsai PC, Yuan W, Small K, Bell J, Mitchell GF, AortaGen Consortium, Chowienczyk P, Spector TD. J Hypertens 34 79-87 (2016)
  34. CIB1 and CIB2 are HIV-1 helper factors involved in viral entry. Godinho-Santos A, Hance AJ, Gonçalves J, Mammano F. Sci Rep 6 30927 (2016)
  35. S-SAD phasing of monoclinic histidine kinase from Brucella abortus combining data from multiple crystals and orientations: an example of data-collection strategy and a posteriori analysis of different data combinations. Klinke S, Foos N, Rinaldi JJ, Paris G, Goldbaum FA, Legrand P, Guimarães BG, Thompson A. Acta Crystallogr D Biol Crystallogr 71 1433-1443 (2015)
  36. The interaction between AID and CIB1 is nonessential for antibody gene diversification by gene conversion or class switch recombination. Demorest ZL, MacDuff DA, Brown WL, Morham SG, Parise LV, Harris RS. PLoS One 5 e11660 (2010)
  37. Calmyrin1 binds to SCG10 protein (stathmin2) to modulate neurite outgrowth. Sobczak A, Debowska K, Blazejczyk M, Kreutz MR, Kuznicki J, Wojda U. Biochim Biophys Acta 1813 1025-1037 (2011)
  38. CIB2 and CIB3 Regulate Stereocilia Maintenance and Mechanoelectrical Transduction in Mouse Vestibular Hair Cells. Wang X, Liu S, Cheng Q, Qu C, Ren R, Du H, Li N, Yan K, Wang Y, Xiong W, Xu Z. J Neurosci 43 3219-3231 (2023)
  39. Identification of calcium and integrin-binding protein 1 as a reprogrammed glucose metabolism mediator to restrict immune cell infiltration in the stromal compartment of pancreatic ductal adenocarcinoma. Ma J, Song Y, Zhuang T, Yang H, Yang X, Zheng J, Luo J, Xia Y, Fei X, Chan DW, Wu D, Xu P, Ni P, Dai J, Xu D, Hu Y. Front Immunol 14 1158964 (2023)


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