› 1w4g

Solution NMR

Peripheral-subunit binding domains from mesophilic, thermophilic, and hyperthermophilic bacteria fold by ultrafast, apparently two-state folding transitions

Released:
DOI: 10.2210/pdb1w4g/pdb
PDB entry 1w4g coloured by chain, ensemble of 20 models, front view.
PDB entry 1w4g coloured by chain, ensemble of 20 models, side view.
PDB entry 1w4g coloured by chain, ensemble of 20 models, top view.
Source organism: Geobacillus stearothermophilus
Primary publication:
Ultra-fast barrier-limited folding in the peripheral subunit-binding domain family.
Ferguson N, Sharpe TD, Schartau PJ, Sato S, Allen MD, Johnson CM, Rutherford TJ, Fersht AR
J Mol Biol 353 427-46 (2005)
PMID: 16168437

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146011 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex Chain: A
Molecule details ›
Chain: A
Length: 47 amino acids
Theoretical weight: 5.13 KDa
Source organism: Geobacillus stearothermophilus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P11961 (Residues: 124-170; Coverage: 11%)
Gene name: pdhC
Sequence domains: e3 binding domain
Structure domains: E3-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

13 review citations

The protein folding problem.
Dill et al. (2008)
12 more

1 mention without citation

Downhill, Ultrafast and Fast Folding Proteins Revised.
Banach et al. (2020)