Function and Biology

Structure of pig muscle PGK complexed with ATP

Source organism: Sus scrofa
Biochemical function: ADP binding
Biological process: phosphorylation
Cellular component: cytosol

EC 2.7.2.3: Phosphoglycerate kinase

Reaction catalysed:
ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate
Systematic name:
ATP:3-phospho-D-glycerate 1-phosphotransferase
Alternative Name(s):
  • 3-PGK
  • 3-phosphoglycerate kinase
  • 3-phosphoglycerate phosphokinase
  • 3-phosphoglyceric acid kinase
  • 3-phosphoglyceric acid phosphokinase
  • 3-phosphoglyceric kinase
  • ATP-3-phospho-D-glycerate-1-phosphotransferase
  • ATP:D-3-phosphoglycerate 1-phosphotransferase
  • Glycerate 3-phosphate kinase
  • Glycerophosphate kinase
  • PGK
  • Phosphoglyceric acid kinase
  • Phosphoglyceric kinase
  • Phosphoglycerokinase

Sequence family

Pfam Protein family (Pfam)
PF00162
Domain description: Phosphoglycerate kinase
Occurring in:
  1. Phosphoglycerate kinase 1
The deposited structure of PDB entry 1vjd contains 1 copy of Pfam domain PF00162 (Phosphoglycerate kinase) in Phosphoglycerate kinase 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001576
Domain description: Phosphoglycerate kinase
Occurring in:
  1. Phosphoglycerate kinase 1
IPR015824
Domain description: Phosphoglycerate kinase, N-terminal
Occurring in:
  1. Phosphoglycerate kinase 1
IPR015911
Domain description: Phosphoglycerate kinase, conserved site
Occurring in:
  1. Phosphoglycerate kinase 1
IPR036043
Domain description: Phosphoglycerate kinase superfamily
Occurring in:
  1. Phosphoglycerate kinase 1

Structure domain

CATH CATH domain
3.40.50.1260
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Phosphoglycerate kinase, N-terminal domain
Occurring in:
  1. Phosphoglycerate kinase 1
The deposited structure of PDB entry 1vjd contains 2 copies of CATH domain 3.40.50.1260 (Rossmann fold) in Phosphoglycerate kinase 1. Showing 2 copies in chain A.
SCOP SCOP annotation
53749
Class: Alpha and beta proteins (a/b)
Fold: Phosphoglycerate kinase
Superfamily: Phosphoglycerate kinase
Occurring in:
  1. Phosphoglycerate kinase 1
The deposited structure of PDB entry 1vjd contains 1 copy of SCOP domain 53749 (Phosphoglycerate kinase) in Phosphoglycerate kinase 1. Showing 1 copy in chain A.