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Site-directed mutagenesis of His592 involved in binding of copper ion in Arthrobacter globiformis amine oxidase

Source organism: Arthrobacter globiformis
Biochemical function: aliphatic amine oxidase activity
Biological process: amine metabolic process
Cellular component: not assigned

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EC 1.4.3.21: Primary-amine oxidase

Reaction catalysed:
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2)
Systematic name:
Primary-amine:oxygen oxidoreductase (deaminating)
Alternative Name(s):
  • Amine oxidase
  • Amine oxidase (copper-containing)
  • Amine oxidase (pyridoxal containing)
  • Benzylamine oxidase
  • CAO
  • Copper amine oxidase
  • Cu-amine oxidase
  • Cu-containing amine oxidase
  • Diamine oxidase
  • Diamino oxhydrase
  • Histamine deaminase
  • Histamine oxidase
  • Monoamine oxidase
  • Plasma monoamine oxidase
  • Polyamine oxidase
  • SSAO
  • Semicarbazide-sensitive amine oxidase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01179
Domain description: Copper amine oxidase, enzyme domain
Occurring in:
  1. Phenylethylamine oxidase
The deposited structure of PDB entry 1ui8 contains 2 copies of Pfam domain PF01179 (Copper amine oxidase, enzyme domain) in Phenylethylamine oxidase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036460
Domain description: Copper amine oxidase, catalytic domain superfamily
Occurring in:
  1. Phenylethylamine oxidase
IPR000269
Domain description: Copper amine oxidase
Occurring in:
  1. Phenylethylamine oxidase
IPR016182
Domain description: Copper amine oxidase, N-terminal
Occurring in:
  1. Phenylethylamine oxidase
IPR015798
Domain description: Copper amine oxidase, catalytic domain
Occurring in:
  1. Phenylethylamine oxidase

Structure domains

CATH CATH domains
3.10.450.40
Class: Alpha Beta
Architecture: Roll
Topology: Nuclear Transport Factor 2; Chain: A,
Homology: Nuclear Transport Factor 2; Chain: A,
Occurring in:
  1. Phenylethylamine oxidase
The deposited structure of PDB entry 1ui8 contains 4 copies of CATH domain 3.10.450.40 (Nuclear Transport Factor 2; Chain: A,) in Phenylethylamine oxidase. Showing 2 copies in chain A.
2.70.98.20
Class: Mainly Beta
Architecture: Distorted Sandwich
Topology: Beta-galactosidase; Chain A, domain 5
Homology: Copper amine oxidase, catalytic domain
Occurring in:
  1. Phenylethylamine oxidase
The deposited structure of PDB entry 1ui8 contains 2 copies of CATH domain 2.70.98.20 (Beta-galactosidase; Chain A, domain 5) in Phenylethylamine oxidase. Showing 1 copy in chain A.
SCOP SCOP annotations
54417
Class: Alpha and beta proteins (a+b)
Fold: Cystatin-like
Superfamily: Amine oxidase N-terminal region
Occurring in:
  1. Phenylethylamine oxidase
The deposited structure of PDB entry 1ui8 contains 4 copies of SCOP domain 54417 (Amine oxidase N-terminal region) in Phenylethylamine oxidase. Showing 2 copies in chain A.
49999
Class: All beta proteins
Fold: Supersandwich
Superfamily: Amine oxidase catalytic domain
Occurring in:
  1. Phenylethylamine oxidase
The deposited structure of PDB entry 1ui8 contains 2 copies of SCOP domain 49999 (Amine oxidase catalytic domain) in Phenylethylamine oxidase. Showing 1 copy in chain A.

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