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The 2.3 Angstrom resolution crystal structure of the heterodimer of the human PPARgamma and RXRalpha ligand binding domains respectively bound with GW409544 and 9-cis retinoic acid and co-activator peptides.

Source organism: Homo sapiens
Biochemical function: DNA binding
Biological process: regulation of DNA-templated transcription
Cellular component: nucleus

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EC 2.3.1.48: Histone acetyltransferase

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Systematic name:
Acetyl-CoA:[protein]-L-lysine acetyltransferase
Alternative Name(s):
  • Acetyl-CoA:histone acetyltransferase
  • Histone acetokinase
  • Histone acetylase
  • Histone transacetylase
  • Lysine acetyltransferase
  • Nucleosome-histone acetyltransferase
  • Protein lysine acetyltransferase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF08832
Domain description: Steroid receptor coactivator
Occurring in:
  1. Nuclear receptor coactivator 1
The deposited structure of PDB entry 1k74 contains 2 copies of Pfam domain PF08832 (Steroid receptor coactivator) in Nuclear receptor coactivator 1. Showing 1 copy in chain D [auth E].

PF00104
Domain description: Ligand-binding domain of nuclear hormone receptor
Occurring in:
  1. Retinoic acid receptor RXR-alpha
  2. Peroxisome proliferator-activated receptor gamma
The deposited structure of PDB entry 1k74 contains 1 copy of Pfam domain PF00104 (Ligand-binding domain of nuclear hormone receptor) in Retinoic acid receptor RXR-alpha. Showing 1 copy in chain A.
The deposited structure of PDB entry 1k74 contains 1 copy of Pfam domain PF00104 (Ligand-binding domain of nuclear hormone receptor) in Peroxisome proliferator-activated receptor gamma. Showing 1 copy in chain B [auth D].

InterPro InterPro annotations
IPR001723
Domain description: Nuclear hormone receptor
Occurring in:
  1. Retinoic acid receptor RXR-alpha
  2. Peroxisome proliferator-activated receptor gamma
IPR003074
Domain description: Peroxisome proliferator-activated receptor
Occurring in:
  1. Peroxisome proliferator-activated receptor gamma
IPR000536
Domain description: Nuclear hormone receptor, ligand-binding domain
Occurring in:
  1. Retinoic acid receptor RXR-alpha
  2. Peroxisome proliferator-activated receptor gamma
IPR035500
Domain description: Nuclear hormone receptor-like domain superfamily
Occurring in:
  1. Retinoic acid receptor RXR-alpha
  2. Peroxisome proliferator-activated receptor gamma
IPR000003
Domain description: Retinoid X receptor/HNF4
Occurring in:
  1. Retinoic acid receptor RXR-alpha
IPR014935
Domain description: Nuclear receptor coactivator, receptor-binding domain
Occurring in:
  1. Nuclear receptor coactivator 1

Structure domain

CATH CATH domain
1.10.565.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Retinoid X Receptor
Homology: Retinoid X Receptor
Occurring in:
  1. Retinoic acid receptor RXR-alpha
  2. Peroxisome proliferator-activated receptor gamma
The deposited structure of PDB entry 1k74 contains 1 copy of CATH domain 1.10.565.10 (Retinoid X Receptor) in Retinoic acid receptor RXR-alpha. Showing 1 copy in chain A.
The deposited structure of PDB entry 1k74 contains 1 copy of CATH domain 1.10.565.10 (Retinoid X Receptor) in Peroxisome proliferator-activated receptor gamma. Showing 1 copy in chain B [auth D].
SCOP SCOP annotation
48509
Class: All alpha proteins
Fold: Nuclear receptor ligand-binding domain
Superfamily: Nuclear receptor ligand-binding domain
Occurring in:
  1. Retinoic acid receptor RXR-alpha
  2. Peroxisome proliferator-activated receptor gamma
The deposited structure of PDB entry 1k74 contains 1 copy of SCOP domain 48509 (Nuclear receptor ligand-binding domain) in Retinoic acid receptor RXR-alpha. Showing 1 copy in chain A.
The deposited structure of PDB entry 1k74 contains 1 copy of SCOP domain 48509 (Nuclear receptor ligand-binding domain) in Peroxisome proliferator-activated receptor gamma. Showing 1 copy in chain B [auth D].

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