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STRUCTURE OF THE IGF BINDING DOMAIN OF THE INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-5 (IGFBP-5): IMPLICATIONS FOR IGF AND IGF-I RECEPTOR INTERACTIONS

Source organism: Homo sapiens
Biochemical function: insulin-like growth factor binding
Biological process: not assigned
Cellular component: extracellular region

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GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00219
Domain description: Insulin-like growth factor binding protein
Occurring in:
  1. Insulin-like growth factor-binding protein 5
The deposited structure of PDB entry 1boe contains 1 copy of Pfam domain PF00219 (Insulin-like growth factor binding protein) in Insulin-like growth factor-binding protein 5. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR022321
Domain description: Insulin-like growth factor-binding protein family 1-6, chordata
Occurring in:
  1. Insulin-like growth factor-binding protein 5
IPR000867
Domain description: Insulin-like growth factor-binding protein, IGFBP
Occurring in:
  1. Insulin-like growth factor-binding protein 5
IPR009030
Domain description: Growth factor receptor cysteine-rich domain superfamily
Occurring in:
  1. Insulin-like growth factor-binding protein 5

Structure domain

CATH CATH domain
4.10.40.20
Class: Few Secondary Structures
Architecture: Irregular
Topology: Omega-AgatoxinV
Homology: Omega-AgatoxinV
Occurring in:
  1. Insulin-like growth factor-binding protein 5
The deposited structure of PDB entry 1boe contains 1 copy of CATH domain 4.10.40.20 (Omega-AgatoxinV) in Insulin-like growth factor-binding protein 5. Showing 1 copy in chain A.
SCOP SCOP annotation
57185
Class: Small proteins
Fold: Knottins (small inhibitors, toxins, lectins)
Superfamily: Growth factor receptor domain
Occurring in:
  1. Insulin-like growth factor-binding protein 5
The deposited structure of PDB entry 1boe contains 1 copy of SCOP domain 57185 (Growth factor receptor domain) in Insulin-like growth factor-binding protein 5. Showing 1 copy in chain A.

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