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Crystal Structure Of Human Potassium Channel Kv Beta-subunit (KCNAB2)

X-ray diffraction
1.9Å resolution
PDB entry 1zsx coloured by chain, front view.
PDB entry 1zsx coloured by chain, side view.
PDB entry 1zsx coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
homo tetramer (preferred)
homo octamer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Voltage-gated potassium channel subunit beta-2
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Multimeric state: homo tetramer
Accessible surface area: 45878.03 Å2
Buried surface area: 14449.08 Å2
Dissociation area: 3,748.16 Å2
Dissociation energy (ΔGdiss): 33.58 kcal/mol
Dissociation entropy (TΔSdiss): 43.67 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-171632
Assembly 2
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Assembly Name: Voltage-gated potassium channel subunit beta-2
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Multimeric state: homo octamer
Accessible surface area: 86225.26 Å2
Buried surface area: 34428.97 Å2
Dissociation area: 528.22 Å2
Dissociation energy (ΔGdiss): 37.04 kcal/mol
Dissociation entropy (TΔSdiss): 3.09 kcal/mol
Symmetry number: 8
PDBe Complex ID: PDB-CPX-171633

Macromolecules

Voltage-gated potassium channel subunit beta-2
Chain: A
Length: 347 amino acids
Theoretical weight: 38.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13303 (Residues: 39-360; Coverage: 88%)
Gene names: KCNA2B, KCNAB2, KCNK2
Pfam: Aldo/keto reductase family
InterPro:
CATH: NADP-dependent oxidoreductase domain
Voltage-gated potassium channel subunit beta-2 in PDB entry 1zsx, assembly 1, front view.
Voltage-gated potassium channel subunit beta-2 in PDB entry 1zsx, assembly 1, side view.
Voltage-gated potassium channel subunit beta-2 in PDB entry 1zsx, assembly 1, top view.
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