› 5hgl

X-ray diffraction
3.1Å resolution

Hexameric HIV-1 CA, open conformation

Released:
DOI: 10.2210/pdb5hgl/pdb
PDB entry 5hgl coloured by chain, front view.
PDB entry 5hgl coloured by chain, side view.
PDB entry 5hgl coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis.
Jacques DA, McEwan WA, Hilditch L, Price AJ, Towers GJ, James LC
Nature 536 349-53 (2016)
PMID: 27509857

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146190 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid protein p24 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 231 amino acids
Theoretical weight: 25.46 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P12493 (Residues: 133-363; Coverage: 46%)
Gene name: gag
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 1B0 6 x 1B0
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: C2221
Unit cell:
a: 89.69Å b: 159.27Å c: 249.399Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.252 0.25 0.282
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

30 review citations

Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response.
Wan et al. (2020)
29 more

19 mentions without citation

HIV Capsid Inhibitors Beyond PF74.
McArthur et al. (2019)
18 more