› 5brx

X-ray diffraction
2.05Å resolution

X-ray crystal structure of Aplysia californica (Ac-AChBP) in complex with 2-pyridyl azatricyclo[3.3.1.13,7]decane; 2-pyridylazaadamantane; 2-Aza (TI-8480)

Released:
DOI: 10.2210/pdb5brx/pdb
PDB entry 5brx coloured by chain, front view.
PDB entry 5brx coloured by chain, side view.
PDB entry 5brx coloured by chain, top view.
Source organism: Aplysia californica
Entry authors: Bobango J, Sankaran B, Park JF, Wu J, Talley TT

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186694 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neurotransmitter-gated ion-channel ligand-binding domain-containing protein Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 230 amino acids
Theoretical weight: 26.24 KDa
Source organism: Aplysia californica
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8WSF8 (Residues: 18-236; Coverage: 100%)
Sequence domains: Neurotransmitter-gated ion-channel ligand binding domain
Structure domains: Neurotransmitter-gated ion-channel ligand-binding domain

Ligands and Environments

3 bound ligands:
Ligand SO4 10 x SO4
Ligand TI4 4 x TI4
Ligand PG4 6 x PG4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P41
Unit cell:
a: 98.297Å b: 98.297Å c: 270.242Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.197 0.235
Expression system: Homo sapiens

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