4ie1 Summary


Crystal structure of human Arginase-1 complexed with inhibitor 1h

The structure was published by Golebiowski, A., Paul Beckett, R., Van Zandt, M., et al., Ruiz, F.X., Podjarny, A., and Schroeter, H., in 2013 in a paper entitled "2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0006 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Arginase-1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Arginase-1 P05089 (5-318) (ARGI1_HUMAN)search Homo sapienssearch 98% 314 100%
B Arginase-1 P05089 (5-318) (ARGI1_HUMAN)search Homo sapienssearch 98% 314 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05089 (5 - 318) Arginase-1 Homo sapiens

Chain Sequence family (Pfam)
A, B (P05089) PF00491: Arginase familysearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B (P05089) female pregnancysearch response to vitamin Esearch urea cyclesearch arginine metabolic processsearch cellular nitrogen compound metabolic processsearch response to lipopolysaccharidesearch protein homotrimerizationsearch response to vitamin Asearch cellular response to interleukin-4search cellular response to dexamethasone stimulussearch response to methylmercurysearch liver developmentsearch cellular response to transforming growth factor beta stimulussearch positive regulation of endothelial cell proliferationsearch collagen biosynthetic processsearch response to selenium ionsearch mammary gland involutionsearch lung developmentsearch maternal process involved in female pregnancysearch response to herbicidesearch arginine catabolic processsearch response to axon injurysearch small molecule metabolic processsearch response to steroid hormonesearch response to zinc ionsearch response to manganese ionsearch cellular response to lipopolysaccharidesearch response to drugsearch response to amino acidsearch regulation of L-arginine importsearch cellular response to hydrogen peroxidesearch cellular response to glucagon stimulussearch response to cadmium ionsearch response to peptide hormonesearch response to woundingsearch response to aminesearch cytosolsearch extracellular vesicular exosomesearch neuron projectionsearch neuronal cell bodysearch cytoplasmsearch nucleussearch extracellular spacesearch manganese ion bindingsearch arginase activitysearch metal ion bindingsearch hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidinessearch hydrolase activitysearch

Chain InterPro annotation
A, B Ureohydrolasesearch Arginasesearch Ureohydrolase, manganese-binding sitesearch Ureohydrolase domainsearch