› 4gif

X-ray diffraction
2.8Å resolution

C-terminal coiled-coil domain of transient receptor potential channel TRPP3 (PKD2L1, Polycystin-L)

Released:
DOI: 10.2210/pdb4gif/pdb
PDB entry 4gif coloured by chain, front view.
PDB entry 4gif coloured by chain, side view.
PDB entry 4gif coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex.
Yu Y, Ulbrich MH, Li MH, Dobbins S, Zhang WK, Tong L, Isacoff EY, Yang J
Nat Commun 3 1252 (2012)
PMID: 23212381

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192800 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polycystin-2-like protein 1 Chain: A
Molecule details ›
Chain: A
Length: 45 amino acids
Theoretical weight: 5.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9P0L9 (Residues: 699-743; Coverage: 6%)
Gene names: PKD2L, PKD2L1, PKDL, TRPP3
Sequence domains: Ferredoxin I 4Fe-4S cluster domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: P321
Unit cell:
a: 44.527Å b: 44.527Å c: 62.306Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.24 0.235 0.286
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Forcing open TRP channels: Mechanical gating as a unifying activation mechanism.
Liu et al. (2015)
11 more

4 mentions without citation

TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases.
Zhang et al. (2023)
3 more