› 4ez1

X-ray diffraction
2.49Å resolution

Crystal structure of acetylcholine binding protein (AChBP) from Aplysia Californica in complex with alpha-conotoxin BuIA

Released:
DOI: 10.2210/pdb4ez1/pdb
PDB entry 4ez1 coloured by chain, front view.
PDB entry 4ez1 coloured by chain, side view.
PDB entry 4ez1 coloured by chain, top view.
Source organisms:
Entry authors: Talley TT, Reger AS, Kim C, Sankaran B, Ho K, Taylor P, McIntosh JM

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159621 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Neurotransmitter-gated ion-channel ligand-binding domain-containing protein Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 230 amino acids
Theoretical weight: 26.21 KDa
Source organism: Aplysia californica
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8WSF8 (Residues: 18-236; Coverage: 100%)
Sequence domains: Neurotransmitter-gated ion-channel ligand binding domain
Structure domains: Neurotransmitter-gated ion-channel ligand-binding domain
Alpha-conotoxin BuIA Chains: K, L, M, N, O
Molecule details ›
Chains: K, L, M, N, O
Length: 14 amino acids
Theoretical weight: 1.31 KDa
Source organism: Conus bullatus
Expression system: Not provided
UniProt:
  • Canonical: P69657 (Residues: 44-56; Coverage: 30%)

Ligands and Environments

1 bound ligand:
Ligand MN 1 x MN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P21
Unit cell:
a: 68.437Å b: 78.636Å c: 117.636Å
α: 90° β: 93.2° γ: 90°
R-values:
R R work R free
0.174 0.171 0.227
Expression systems:
  • Homo sapiens
  • Not provided

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