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Human angiotensin-converting enzyme in complex with angiotensin-II

X-ray diffraction
1.99Å resolution
PDB entry 4aph coloured by chain, front view.
PDB entry 4aph coloured by chain, side view.
PDB entry 4aph coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Angiotensin-converting enzyme, soluble form and Angiotensin-1
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Multimeric state: hetero dimer
Accessible surface area: 23441.26 Å2
Buried surface area: 4414.86 Å2
Dissociation area: 752.9 Å2
Dissociation energy (ΔGdiss): 22.77 kcal/mol
Dissociation entropy (TΔSdiss): 6.75 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133812

Macromolecules

Angiotensin-converting enzyme, soluble form
Chain: A
Length: 589 amino acids
Theoretical weight: 68.07 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P12821 (Residues: 642-1230; Coverage: 46%)
Gene names: ACE, DCP, DCP1
Pfam: Angiotensin-converting enzyme
InterPro: Peptidase M2, peptidyl-dipeptidase A
Angiotensin-converting enzyme, soluble form in PDB entry 4aph, assembly 1, front view.
Angiotensin-converting enzyme, soluble form in PDB entry 4aph, assembly 1, side view.
Angiotensin-converting enzyme, soluble form in PDB entry 4aph, assembly 1, top view.
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Angiotensin-2
Chain: P
Length: 8 amino acids
Theoretical weight: 1.05 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01019 (Residues: 25-32; Coverage: 2%)
Gene names: AGT, SERPINA8
Angiotensin-1 in PDB entry 4aph, assembly 1, front view.
Angiotensin-1 in PDB entry 4aph, assembly 1, side view.
Angiotensin-1 in PDB entry 4aph, assembly 1, top view.
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