› 4xb0

X-ray diffraction
2.7Å resolution

Structure of the Plk2 polo-box domain

Released:
DOI: 10.2210/pdb4xb0/pdb
PDB entry 4xb0 coloured by chain, front view.
PDB entry 4xb0 coloured by chain, side view.
PDB entry 4xb0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis of the polo-box domain of human Polo-like kinase 2.
Kim JH, Ku B, Lee KS, Kim SJ
Proteins 83 1201-8 (2015)
PMID: 25846005

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192723 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase PLK2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 218 amino acids
Theoretical weight: 25.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NYY3 (Residues: 468-685; Coverage: 32%)
Gene names: PLK2, SNK
Sequence domains: POLO box duplicated region
Structure domains: POLO box domain

Ligands and Environments

2 bound ligands:
Ligand PO4 1 x PO4
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 7A (6B, 6C1)
Spacegroup: I23
Unit cell:
a: 152.292Å b: 152.292Å c: 152.292Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.225 0.263
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Polo-Like Kinase 2: From Principle to Practice.
Zhang et al. (2022)
2 other articles

4 mentions without citation

Plk2 Loss Commonly Occurs in Colorectal Carcinomas but not Adenomas: Relationship to mTOR Signaling.
Matthew et al. (2018)
3 more