› 4uhs

X-ray diffraction
5Å resolution

Crystal structure of the receiver domain of CpxR from E. coli (tetragonal form)

Released:
DOI: 10.2210/pdb4uhs/pdb
PDB entry 4uhs coloured by chain, front view.
PDB entry 4uhs coloured by chain, side view.
PDB entry 4uhs coloured by chain, top view.
Source organism: Escherichia coli K-12
Primary publication:
Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance.
Mechaly AE, Haouz A, Sassoon N, Buschiazzo A, Betton JM, Alzari PM
J Struct Biol 204 165-171 (2018)
PMID: 30086390

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142419 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcriptional regulatory protein CpxR Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 136 amino acids
Theoretical weight: 15.56 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
  • Canonical: P0AE88 (Residues: 1-123; Coverage: 53%)
Gene names: JW3883, b3912, cpxR, yiiA
Sequence domains: Response regulator receiver domain

Ligands and Environments

1 bound ligand:
Ligand MG 3 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 2
Spacegroup: I4122
Unit cell:
a: 114.222Å b: 114.222Å c: 356.734Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.261 0.261 0.267
Expression system: Escherichia coli

Quick links

Citations

4 citation in other articles

Activating the Cpx response induces tolerance to antisense PNA delivered by an arginine-rich peptide in Escherichia coli.
Frimodt-Møller et al. (2021)
3 more