Function and Biology Details
Reaction catalysed:
Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
- Aminopeptidase N-type
- Aminopeptidase N-like , N-terminal domain superfamliy
- Spike glycoprotein S1, coronavirus
- ERAP1-like C-terminal domain
- Peptidase M1, membrane alanine aminopeptidase
- Peptidase M4/M1, CTD superfamily
- Aminopeptidase N-like , N-terminal domain
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Spike glycoprotein and Aminopeptidase N (preferred)
PDBe Complex ID:
PDB-CPX-147244 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Aminopeptidase N
Molecule details ›
Chains: A, B
Length: 959 amino acids
Theoretical weight: 108.9 KDa
Source organism: Sus scrofa
Expression system: Cricetulus griseus
UniProt:
Sequence domains:
Structure domains:
Length: 959 amino acids
Theoretical weight: 108.9 KDa
Source organism: Sus scrofa
Expression system: Cricetulus griseus
UniProt:
- Canonical:
P15145 (Residues: 36-963; Coverage: 96%)
Sequence domains:
Structure domains:
Spike glycoprotein
Molecule details ›
Chains: E, F
Length: 440 amino acids
Theoretical weight: 48.37 KDa
Source organism: Porcine respiratory coronavirus
Expression system: Cricetulus griseus
UniProt:
Sequence domains: Coronavirus spike glycoprotein S1
Structure domains: Immunoglobulin-like
Length: 440 amino acids
Theoretical weight: 48.37 KDa
Source organism: Porcine respiratory coronavirus
Expression system: Cricetulus griseus
UniProt:
- Canonical: Q84852 (Residues: 17-442; Coverage: 35%)
Sequence domains: Coronavirus spike glycoprotein S1
Structure domains: Immunoglobulin-like
