› 3sao

X-ray diffraction
1.8Å resolution

The Siderocalin Ex-FABP functions through dual ligand specificities

Released:
DOI: 10.2210/pdb3sao/pdb
PDB entry 3sao coloured by chain, front view.
PDB entry 3sao coloured by chain, side view.
PDB entry 3sao coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Galline Ex-FABP is an antibacterial siderocalin and a lysophosphatidic acid sensor functioning through dual ligand specificities.
Correnti C, Clifton MC, Abergel RJ, Allred B, Hoette TM, Ruiz M, Cancedda R, Raymond KN, Descalzi F, Strong RK
Structure 19 1796-806 (2011)
PMID: 22153502

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149417 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Extracellular fatty acid-binding protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 160 amino acids
Theoretical weight: 18.2 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: P21760 (Residues: 23-178; Coverage: 99%)
Gene name: EXFABP
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

4 bound ligands:
Ligand NKN 2 x NKN
Ligand DBH 1 x DBH
Ligand FE 1 x FE
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P212121
Unit cell:
a: 37.95Å b: 68.89Å c: 117.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.202 0.233
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Lipocalin 2: An Emerging Player in Iron Homeostasis and Inflammation.
Xiao et al. (2017)
6 more

6 mentions without citation

Antimicrobial Proteins and Peptides in Avian Eggshell: Structural Diversity and Potential Roles in Biomineralization.
Moreau et al. (2022)
5 more