3fkl Summary

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P38 kinase crystal structure in complex with RO9552

A publication describing this structure is not available. The depositing authors are Kuglstatter, A.search; Ghate, M.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 372 residues which is 100% of the natural sequence. Out of 372 residues 344 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 372 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q16539) MyD88-independent toll-like receptor signaling pathwaysearch innate immune responsesearch cell morphogenesissearch apoptotic processsearch phosphorylationsearch response to stresssearch peptidyl-serine phosphorylationsearch positive regulation of muscle cell differentiationsearch MAPK cascadesearch protein phosphorylationsearch 3'-UTR-mediated mRNA stabilizationsearch osteoclast differentiationsearch cell surface receptor signaling pathwaysearch toll-like receptor 2 signaling pathwaysearch muscle cell differentiationsearch regulation of transcription, DNA-dependentsearch stress-activated MAPK cascadesearch gene expressionsearch vascular endothelial growth factor receptor signaling pathwaysearch skeletal muscle tissue developmentsearch chemotaxissearch positive regulation of reactive oxygen species metabolic processsearch blood coagulationsearch response to DNA damage stimulussearch RNA metabolic processsearch fatty acid oxidationsearch toll-like receptor signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch toll-like receptor 4 signaling pathwaysearch striated muscle cell differentiationsearch intracellular protein kinase cascadesearch toll-like receptor 9 signaling pathwaysearch DNA damage checkpointsearch glucose metabolic processsearch TRIF-dependent toll-like receptor signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch transcription, DNA-dependentsearch signal transductionsearch toll-like receptor 5 signaling pathwaysearch response to muramyl dipeptidesearch platelet activationsearch cellular response to vascular endothelial growth factor stimulussearch MyD88-dependent toll-like receptor signaling pathwaysearch positive regulation of blood vessel endothelial cell migrationsearch chondrocyte differentiationsearch lipopolysaccharide-mediated signaling pathwaysearch Ras protein signal transductionsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch positive regulation of erythrocyte differentiationsearch toll-like receptor 3 signaling pathwaysearch toll-like receptor 10 signaling pathwaysearch mRNA metabolic processsearch signal transduction in response to DNA damagesearch positive regulation of protein import into nucleussearch neurotrophin TRK receptor signaling pathwaysearch angiogenesissearch cellular response to ionizing radiationsearch response to lipopolysaccharidesearch toll-like receptor TLR6:TLR2 signaling pathwaysearch activation of MAPK activitysearch cellular component movementsearch stress-induced premature senescencesearch kinase activitysearch MAP kinase activitysearch protein bindingsearch protein kinase activitysearch ATP bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch nucleotide bindingsearch MAP kinase kinase activitysearch NFAT protein bindingsearch transferase activitysearch cytosolsearch nucleoplasmsearch nucleussearch cytoplasmsearch spindle polesearch mitochondrionsearch cellsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine- / dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch