3fkl Summary


P38 kinase crystal structure in complex with RO9552

A publication describing this structure is not available. The depositing authors are Kuglstatter, A.search; Ghate, M.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 372 residues which is 100% of the natural sequence. Out of 372 residues 344 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 372 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q16539) protein phosphorylationsearch striated muscle cell differentiationsearch MyD88-dependent toll-like receptor signaling pathwaysearch positive regulation of protein import into nucleussearch peptidyl-serine phosphorylationsearch stress-activated MAPK cascadesearch positive regulation of reactive oxygen species metabolic processsearch MyD88-independent toll-like receptor signaling pathwaysearch cell morphogenesissearch toll-like receptor TLR1:TLR2 signaling pathwaysearch regulation of transcription from RNA polymerase II promotersearch regulation of sequence-specific DNA binding transcription factor activitysearch toll-like receptor 3 signaling pathwaysearch cellular response to DNA damage stimulussearch vascular endothelial growth factor receptor signaling pathwaysearch intracellular signal transductionsearch mRNA metabolic processsearch response to muramyl dipeptidesearch 3'-UTR-mediated mRNA stabilizationsearch myoblast differentiation involved in skeletal muscle regenerationsearch positive regulation of transcription from RNA polymerase II promotersearch toll-like receptor signaling pathwaysearch positive regulation of blood vessel endothelial cell migrationsearch positive regulation of myoblast differentiationsearch Ras protein signal transductionsearch cellular response to vascular endothelial growth factor stimulussearch neurotrophin TRK receptor signaling pathwaysearch toll-like receptor 2 signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch glucose metabolic processsearch RNA metabolic processsearch toll-like receptor 4 signaling pathwaysearch positive regulation of myotube differentiationsearch negative regulation of canonical Wnt signaling pathwaysearch transcription, DNA-templatedsearch muscle cell differentiationsearch p38MAPK cascadesearch platelet activationsearch blood coagulationsearch cartilage condensationsearch cellular response to lipopolysaccharidesearch apoptotic processsearch response to lipopolysaccharidesearch positive regulation of myoblast fusionsearch TRIF-dependent toll-like receptor signaling pathwaysearch DNA damage checkpointsearch response to stresssearch chemotaxissearch toll-like receptor 5 signaling pathwaysearch skeletal muscle tissue developmentsearch positive regulation of muscle cell differentiationsearch osteoclast differentiationsearch angiogenesissearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch gene expressionsearch cellular component movementsearch cell surface receptor signaling pathwaysearch positive regulation of erythrocyte differentiationsearch activation of MAPK activitysearch toll-like receptor 10 signaling pathwaysearch regulation of transcription, DNA-templatedsearch stress-induced premature senescencesearch cellular response to ionizing radiationsearch toll-like receptor 9 signaling pathwaysearch lipopolysaccharide-mediated signaling pathwaysearch fatty acid oxidationsearch phosphorylationsearch innate immune responsesearch chondrocyte differentiationsearch signal transduction in response to DNA damagesearch signal transductionsearch protein bindingsearch kinase activitysearch MAP kinase activitysearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch transferase activitysearch protein serine/threonine kinase activitysearch MAP kinase kinase activitysearch NFAT protein bindingsearch nucleotide bindingsearch nucleoplasmsearch cytosolsearch nucleussearch spindle polesearch cytoplasmsearch extracellular vesicular exosomesearch cellsearch mitochondrionsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch