2zoq Summary


Structural dissection of human mitogen-activated kinase ERK1

The structure was published by Kinoshita, T., Yoshida, I., Nakae, S., et al., Yokota, K., Ishiguro, H., and Tada, T., in 2008 in a paper entitled "Crystal structure of human mono-phosphorylated ERK1 at Tyr204" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.39 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Mitogen-activated protein kinase 3.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 3 P27361 (1-379) (MK03_HUMAN)search Homo sapienssearch 100% 382 92%
B Mitogen-activated protein kinase 3 P27361 (1-379) (MK03_HUMAN)search Homo sapienssearch 100% 382 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P27361 (1 - 379) Mitogen-activated protein kinase 3 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P27361) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P27361) protein kinase activitysearch MAP kinase activitysearch phosphotyrosine bindingsearch protein bindingsearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch nucleotide bindingsearch kinase activitysearch transferase activitysearch phosphatase bindingsearch cytosolsearch nucleoplasmsearch extracellular vesicular exosomesearch nucleussearch caveolasearch nucleolussearch late endosomesearch cytoplasmsearch pseudopodiumsearch focal adhesionsearch Golgi apparatussearch cytoskeletonsearch early endosomesearch microtubule cytoskeletonsearch mitochondrionsearch small GTPase mediated signal transductionsearch insulin receptor signaling pathwaysearch toll-like receptor 9 signaling pathwaysearch blood coagulationsearch peptidyl-tyrosine autophosphorylationsearch cytokine-mediated signaling pathwaysearch toll-like receptor TLR1:TLR2 signaling pathwaysearch transcription, DNA-templatedsearch interleukin-1-mediated signaling pathwaysearch positive regulation of protein phosphorylationsearch MAPK cascadesearch MyD88-dependent toll-like receptor signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch cell cyclesearch transcription from RNA polymerase I promotersearch Fc-epsilon receptor signaling pathwaysearch regulation of Golgi inheritancesearch protein phosphorylationsearch positive regulation of histone acetylationsearch positive regulation of transcription from RNA polymerase II promotersearch lipopolysaccharide-mediated signaling pathwaysearch stress-activated MAPK cascadesearch platelet activationsearch innate immune responsesearch transcription initiation from RNA polymerase I promotersearch JAK-STAT cascade involved in growth hormone signaling pathwaysearch epidermal growth factor receptor signaling pathwaysearch toll-like receptor 4 signaling pathwaysearch toll-like receptor 10 signaling pathwaysearch activation of MAPKK activitysearch toll-like receptor signaling pathwaysearch toll-like receptor 2 signaling pathwaysearch cartilage developmentsearch positive regulation of ERK1 and ERK2 cascadesearch organ morphogenesissearch activation of MAPK activitysearch positive regulation of histone phosphorylationsearch caveolin-mediated endocytosissearch toll-like receptor TLR6:TLR2 signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch cellular response to DNA damage stimulussearch Fc-gamma receptor signaling pathway involved in phagocytosissearch regulation of cytoskeleton organizationsearch MyD88-independent toll-like receptor signaling pathwaysearch axon guidancesearch apoptotic processsearch toll-like receptor 3 signaling pathwaysearch Ras protein signal transductionsearch cellular response to mechanical stimulussearch regulation of early endosome to late endosome transportsearch phosphorylationsearch sensory perception of painsearch regulation of stress-activated MAPK cascadesearch response to epidermal growth factorsearch viral processsearch response to exogenous dsRNAsearch toll-like receptor 5 signaling pathwaysearch gene expressionsearch negative regulation of apolipoprotein bindingsearch response to lipopolysaccharidesearch BMP signaling pathwaysearch fibroblast growth factor receptor signaling pathwaysearch DNA damage induced protein phosphorylationsearch neurotrophin TRK receptor signaling pathwaysearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Serine/threonine-protein kinase, active sitesearch Mitogen-activated protein (MAP) kinase, ERK1/2search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch