2zoq Summary


Structural dissection of human mitogen-activated kinase ERK1

The structure was published by Kinoshita, T., Yoshida, I., Nakae, S., et al., Yokota, K., Ishiguro, H., and Tada, T., in 2008 in a paper entitled "Crystal structure of human mono-phosphorylated ERK1 at Tyr204" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.39 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Mitogen-activated protein kinase 3.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 3 P27361 (1-379) (MK03_HUMAN)search Homo sapienssearch 100% 382 92%
B Mitogen-activated protein kinase 3 P27361 (1-379) (MK03_HUMAN)search Homo sapienssearch 100% 382 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P27361 (1 - 379) Mitogen-activated protein kinase 3 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P27361) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P27361) protein phosphorylationsearch sensory perception of painsearch activation of MAPKK activitysearch toll-like receptor signaling pathwaysearch transcription initiation from RNA polymerase I promotersearch caveolin-mediated endocytosissearch toll-like receptor 2 signaling pathwaysearch activation of MAPK activitysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch MAPK cascadesearch stress-activated MAPK cascadesearch positive regulation of histone acetylationsearch epidermal growth factor receptor signaling pathwaysearch toll-like receptor 4 signaling pathwaysearch toll-like receptor 10 signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch regulation of sequence-specific DNA binding transcription factor activitysearch positive regulation of histone phosphorylationsearch positive regulation of ERK1 and ERK2 cascadesearch innate immune responsesearch cellular response to heatsearch phosphorylationsearch toll-like receptor 3 signaling pathwaysearch cellular response to mechanical stimulussearch cartilage developmentsearch Ras protein signal transductionsearch regulation of early endosome to late endosome transportsearch response to lipopolysaccharidesearch MyD88-independent toll-like receptor signaling pathwaysearch axon guidancesearch regulation of cytoskeleton organizationsearch organ morphogenesissearch Fc-gamma receptor signaling pathway involved in phagocytosissearch vascular endothelial growth factor receptor signaling pathwaysearch gene expressionsearch toll-like receptor 5 signaling pathwaysearch cellular response to DNA damage stimulussearch JAK-STAT cascade involved in growth hormone signaling pathwaysearch negative regulation of apolipoprotein bindingsearch peptidyl-tyrosine autophosphorylationsearch positive regulation of protein phosphorylationsearch interleukin-1-mediated signaling pathwaysearch blood coagulationsearch MyD88-dependent toll-like receptor signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch viral processsearch neurotrophin TRK receptor signaling pathwaysearch DNA damage induced protein phosphorylationsearch regulation of stress-activated MAPK cascadesearch response to epidermal growth factorsearch response to exogenous dsRNAsearch transcription, DNA-templatedsearch small GTPase mediated signal transductionsearch insulin receptor signaling pathwaysearch toll-like receptor 9 signaling pathwaysearch cytokine-mediated signaling pathwaysearch lipopolysaccharide-mediated signaling pathwaysearch fibroblast growth factor receptor signaling pathwaysearch platelet activationsearch BMP signaling pathwaysearch transcription from RNA polymerase I promotersearch Fc-epsilon receptor signaling pathwaysearch apoptotic processsearch regulation of Golgi inheritancesearch cell cyclesearch toll-like receptor TLR1:TLR2 signaling pathwaysearch regulation of cellular response to heatsearch protein kinase activitysearch MAP kinase activitysearch kinase activitysearch transferase activitysearch protein bindingsearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein serine/threonine kinase activitysearch phosphotyrosine bindingsearch nucleotide bindingsearch phosphatase bindingsearch cytosolsearch nucleoplasmsearch late endosomesearch caveolasearch nucleussearch Golgi apparatussearch focal adhesionsearch cytoplasmsearch cytoskeletonsearch early endosomesearch nuclear envelopesearch pseudopodiumsearch microtubule cytoskeletonsearch mitochondrionsearch extracellular vesicular exosomesearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Serine/threonine-protein kinase, active sitesearch Mitogen-activated protein (MAP) kinase, ERK1/2search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch