2zoq Summary


Structural dissection of human mitogen-activated kinase ERK1

The structure was published by Kinoshita, T., Yoshida, I., Nakae, S., et al., Yokota, K., Ishiguro, H., and Tada, T., in 2008 in a paper entitled "Crystal structure of human mono-phosphorylated ERK1 at Tyr204" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.39 Å and deposited in 2008.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Mitogen-activated protein kinase 3.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 3 P27361 (1-379) (MK03_HUMAN)search Homo sapienssearch 100% 382 92%
B Mitogen-activated protein kinase 3 P27361 (1-379) (MK03_HUMAN)search Homo sapienssearch 100% 382 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P27361 (1 - 379) Mitogen-activated protein kinase 3 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P27361) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P27361) ATP bindingsearch protein kinase activitysearch MAP kinase activitysearch protein bindingsearch phosphotyrosine bindingsearch transferase activitysearch protein serine/threonine kinase activitysearch nucleotide bindingsearch kinase activitysearch phosphatase bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch negative regulation of apolipoprotein bindingsearch activation of MAPKK activitysearch toll-like receptor signaling pathwaysearch transcription initiation from RNA polymerase I promotersearch JAK-STAT cascade involved in growth hormone signaling pathwaysearch transcription, DNA-templatedsearch response to lipopolysaccharidesearch cell cyclesearch phosphorylationsearch epidermal growth factor receptor signaling pathwaysearch toll-like receptor 4 signaling pathwaysearch toll-like receptor 10 signaling pathwaysearch MAPK cascadesearch organ morphogenesissearch positive regulation of transcription from RNA polymerase II promotersearch stress-activated MAPK cascadesearch positive regulation of histone acetylationsearch activation of MAPK activitysearch caveolin-mediated endocytosissearch toll-like receptor 2 signaling pathwaysearch positive regulation of ERK1 and ERK2 cascadesearch positive regulation of histone phosphorylationsearch platelet activationsearch innate immune responsesearch regulation of cytoskeleton organizationsearch MyD88-independent toll-like receptor signaling pathwaysearch axon guidancesearch toll-like receptor TLR6:TLR2 signaling pathwaysearch cellular response to mechanical stimulussearch response to exogenous dsRNAsearch regulation of early endosome to late endosome transportsearch Ras protein signal transductionsearch sensory perception of painsearch toll-like receptor 3 signaling pathwaysearch Fc-gamma receptor signaling pathway involved in phagocytosissearch gene expressionsearch regulation of sequence-specific DNA binding transcription factor activitysearch toll-like receptor 5 signaling pathwaysearch viral processsearch cartilage developmentsearch cellular response to DNA damage stimulussearch DNA damage induced protein phosphorylationsearch fibroblast growth factor receptor signaling pathwaysearch BMP signaling pathwaysearch regulation of stress-activated MAPK cascadesearch response to epidermal growth factorsearch neurotrophin TRK receptor signaling pathwaysearch lipopolysaccharide-mediated signaling pathwaysearch MyD88-dependent toll-like receptor signaling pathwaysearch interleukin-1-mediated signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch small GTPase mediated signal transductionsearch insulin receptor signaling pathwaysearch toll-like receptor 9 signaling pathwaysearch positive regulation of protein phosphorylationsearch blood coagulationsearch peptidyl-tyrosine autophosphorylationsearch transcription from RNA polymerase I promotersearch Fc-epsilon receptor signaling pathwaysearch regulation of Golgi inheritancesearch apoptotic processsearch cytokine-mediated signaling pathwaysearch toll-like receptor TLR1:TLR2 signaling pathwaysearch nucleussearch cytosolsearch nucleoplasmsearch cytoplasmsearch late endosomesearch caveolasearch focal adhesionsearch Golgi apparatussearch early endosomesearch cytoskeletonsearch pseudopodiumsearch nucleolussearch mitochondrionsearch microtubule cytoskeletonsearch extracellular vesicular exosomesearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Serine/threonine-protein kinase, active sitesearch Mitogen-activated protein (MAP) kinase, ERK1/2search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch