2rg5 Summary


Phenylalanine pyrrolotriazine p38 alpha map kinase inhibitor compound 11B

The structure was published by Hynes, J., Dyckman, A.J., Lin, S., et al., Dodd, J., Schieven, G.L., and Leftheris, K., in 2008 in a paper entitled "Design, Synthesis, and Anti-inflammatory Properties of Orally Active 4-(Phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha Mitogen-Activated Protein Kinase Inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 366 residues which is 100% of the natural sequence. Out of 366 residues 332 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 366 90%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) MAP kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch protein kinase activitysearch kinase activitysearch protein serine/threonine kinase activitysearch transferase activitysearch NFAT protein bindingsearch nucleotide bindingsearch MAP kinase kinase activitysearch protein phosphorylationsearch toll-like receptor 4 signaling pathwaysearch glucose metabolic processsearch response to lipopolysaccharidesearch cell surface receptor signaling pathwaysearch cellular response to ionizing radiationsearch toll-like receptor signaling pathwaysearch muscle cell differentiationsearch toll-like receptor 9 signaling pathwaysearch cell morphogenesissearch intracellular signal transductionsearch gene expressionsearch chemotaxissearch positive regulation of blood vessel endothelial cell migrationsearch platelet activationsearch MyD88-dependent toll-like receptor signaling pathwaysearch cartilage condensationsearch TRIF-dependent toll-like receptor signaling pathwaysearch p38MAPK cascadesearch osteoclast differentiationsearch angiogenesissearch transcription, DNA-templatedsearch positive regulation of myotube differentiationsearch regulation of transcription from RNA polymerase II promotersearch apoptotic processsearch Ras protein signal transductionsearch signal transduction in response to DNA damagesearch neurotrophin TRK receptor signaling pathwaysearch myoblast differentiation involved in skeletal muscle regenerationsearch fatty acid oxidationsearch negative regulation of canonical Wnt signaling pathwaysearch regulation of transcription, DNA-templatedsearch positive regulation of reactive oxygen species metabolic processsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch skeletal muscle tissue developmentsearch peptidyl-serine phosphorylationsearch positive regulation of myoblast differentiationsearch chondrocyte differentiationsearch MyD88-independent toll-like receptor signaling pathwaysearch toll-like receptor 2 signaling pathwaysearch positive regulation of myoblast fusionsearch lipopolysaccharide-mediated signaling pathwaysearch cellular response to vascular endothelial growth factor stimulussearch stress-induced premature senescencesearch vascular endothelial growth factor receptor signaling pathwaysearch cellular response to DNA damage stimulussearch cellular component movementsearch toll-like receptor 5 signaling pathwaysearch activation of MAPK activitysearch toll-like receptor 3 signaling pathwaysearch response to muramyl dipeptidesearch positive regulation of transcription from RNA polymerase II promotersearch stress-activated MAPK cascadesearch positive regulation of erythrocyte differentiationsearch toll-like receptor 10 signaling pathwaysearch 3'-UTR-mediated mRNA stabilizationsearch mRNA metabolic processsearch signal transductionsearch innate immune responsesearch response to stresssearch phosphorylationsearch DNA damage checkpointsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch blood coagulationsearch positive regulation of muscle cell differentiationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch RNA metabolic processsearch cellular response to lipopolysaccharidesearch positive regulation of protein import into nucleussearch striated muscle cell differentiationsearch cellsearch nucleoplasmsearch cytosolsearch cytoplasmsearch mitochondrionsearch nucleussearch spindle polesearch extracellular vesicular exosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch