2ogv Summary

pdbe.org/2ogv
spacer

Crystal Structure of the Autoinhibited Human c-Fms Kinase Domain

The structure was published by Walter, M., Lucet, I.S., Patel, O., et al., Fantino, E., Wilks, A.F., and Rossjohn, J., in 2007 in a paper entitled "The 2.7 A crystal structure of the autoinhibited human c-Fms kinase domain." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2007.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Macrophage colony-stimulating factor 1 receptor precursor. This molecule has the UniProt identifier P07333 (CSF1R_HUMAN)search. The sample contained 317 residues which is < 90% of the natural sequence. Out of 317 residues 311 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Macrophage colony-stimulating factor 1 receptor precursor P07333 (543-918) (CSF1R_HUMAN)search Homo sapienssearch < 90% 317 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P07333 (543 - 918) Macrophage colony-stimulating factor 1 receptor precursor Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P07333) ATP bindingsearch protein kinase activitysearch protein tyrosine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch transmembrane receptor protein tyrosine kinase activitysearch protein phosphorylationsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch membranesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, receptor class III, conserved sitesearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch