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Inhibitor complex of JNK3

X-ray diffraction
2.75Å resolution
PDB entry 2exc coloured by chain, front view.
PDB entry 2exc coloured by chain, side view.
PDB entry 2exc coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Mitogen-activated protein kinase 10
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Multimeric state: monomeric
Accessible surface area: 15937.48 Å2
Buried surface area: 874.36 Å2
Dissociation area: 437.18 Å2
Dissociation energy (ΔGdiss): -6.86 kcal/mol
Dissociation entropy (TΔSdiss): 5.17 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-156874

Macromolecules

Mitogen-activated protein kinase 10
Chain: X
Length: 356 amino acids
Theoretical weight: 41.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P53779 (Residues: 45-400; Coverage: 77%)
Gene names: JNK3, JNK3A, MAPK10, PRKM10, SAPK1B
Pfam: Protein kinase domain
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
Mitogen-activated protein kinase 10 in PDB entry 2exc, assembly 1, front view.
Mitogen-activated protein kinase 10 in PDB entry 2exc, assembly 1, side view.
Mitogen-activated protein kinase 10 in PDB entry 2exc, assembly 1, top view.
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