1yev Summary

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T-To-T(High) quaternary transitions in human hemoglobin: betaW37E OXY (10 test sets)

The structure was published by Kavanaugh, J.S., Rogers, P.H., and Arnone, A., in 2005 in a paper entitled "Crystallographic evidence for a new ensemble of ligand-induced allosteric transitions in hemoglobin: the T-to-T(high) quaternary transitions." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.11 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 97%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 97%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, C (P69905) hemoglobin complexsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch extracellular regionsearch blood microparticlesearch cytosolsearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch membranesearch oxygen transportsearch bicarbonate transportsearch small molecule metabolic processsearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch transportsearch oxidation-reduction processsearch receptor-mediated endocytosissearch iron ion bindingsearch protein bindingsearch metal ion bindingsearch heme bindingsearch peroxidase activitysearch oxygen transporter activitysearch haptoglobin bindingsearch oxygen bindingsearch
B, D (P68871) extracellular vesicular exosomesearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch cytosolsearch extracellular regionsearch endocytic vesicle lumensearch oxygen transportsearch protein heterooligomerizationsearch response to hydrogen peroxidesearch platelet aggregationsearch positive regulation of nitric oxide biosynthetic processsearch bicarbonate transportsearch positive regulation of cell deathsearch regulation of blood pressuresearch regulation of blood vessel sizesearch blood coagulationsearch renal absorptionsearch small molecule metabolic processsearch receptor-mediated endocytosissearch hydrogen peroxide catabolic processsearch transportsearch oxidation-reduction processsearch nitric oxide transportsearch heme bindingsearch iron ion bindingsearch protein bindingsearch oxygen transporter activitysearch metal ion bindingsearch peroxidase activitysearch hemoglobin bindingsearch haptoglobin bindingsearch oxygen bindingsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch