› 1u89

Solution NMR

Solution structure of VBS2 fragment of talin

Released:
DOI: 10.2210/pdb1u89/pdb
PDB entry 1u89 coloured by chain, ensemble of 20 models, front view.
PDB entry 1u89 coloured by chain, ensemble of 20 models, side view.
PDB entry 1u89 coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
A vinculin binding domain from the talin rod unfolds to form a complex with the vinculin head.
Fillingham I, Gingras AR, Papagrigoriou E, Patel B, Emsley J, Critchley DR, Roberts GC, Barsukov IL
Structure 13 65-74 (2005)
PMID: 15642262

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150641 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Talin-1 Chain: A
Molecule details ›
Chain: A
Length: 139 amino acids
Theoretical weight: 14.4 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P26039 (Residues: 755-889; Coverage: 5%)
Gene names: Tln, Tln1
Structure domains: Alpha-catenin/vinculin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry, tortion angle dynamics, simmulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

21 review citations

The structure and regulation of vinculin.
Ziegler et al. (2006)
20 more

3 mentions without citation

How force might activate talin's vinculin binding sites: SMD reveals a structural mechanism.
Hytönen et al. (2008)
2 more