1si3 Summary


Crystal structure of the PAZ domain of human eIF2c1 in complex with a 9-mer siRNA-like duplex

The structure was published by Ma, J.B., Ye, K., and Patel, D.J., in 2004 in a paper entitled "Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2004.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely 5'-R(*CP*GP*UP*GP*AP*CP*UP*CP*U)-3' and Eukaryotic translation initiation factor 2C 1.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Eukaryotic translation initiation factor 2C 1 Q9UL18 (225-369) (AGO1_HUMAN)search Homo sapienssearch 100% 149 80%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9UL18 (225 - 369) Eukaryotic translation initiation factor 2C 1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q9UL18) PAZ domainsearch paz domainsearch PF02170: PAZ domainsearch, PF08699: Domain of unknown function (DUF1785)search
Chain InterPro annotation
A PAZ domainsearch