› 1r0e

X-ray diffraction
2.25Å resolution

Glycogen synthase kinase-3 beta in complex with 3-indolyl-4-arylmaleimide inhibitor

Released:
DOI: 10.2210/pdb1r0e/pdb
PDB entry 1r0e coloured by chain, front view.
PDB entry 1r0e coloured by chain, side view.
PDB entry 1r0e coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Allard J, Nikolcheva T, Gong L, Wang J, Dunten P, Avnur Z, Waters R, Sun Q, Skinner B

Function and Biology Details

Reactions catalysed: 
ATP + a protein = ADP + a phosphoprotein
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156061 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycogen synthase kinase-3 beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 391 amino acids
Theoretical weight: 43.6 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P49841 (Residues: 35-420; Coverage: 92%)
Gene name: GSK3B
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand FLC 2 x FLC
Ligand DFN 2 x DFN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: P212121
Unit cell:
a: 83.957Å b: 84.009Å c: 180.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.223 0.252
Expression system: Trichoplusia ni

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