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Crystal structure of ADP bound to MAP KAP kinase 2

X-ray diffraction
3Å resolution
PDB entry 1ny3 coloured by chain, front view.
PDB entry 1ny3 coloured by chain, side view.
PDB entry 1ny3 coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
monomeric (preferred)
homo dodecamer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: MAP kinase-activated protein kinase 2
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Multimeric state: monomeric
Accessible surface area: 14995.66 Å2
Buried surface area: 788.88 Å2
Dissociation area: 394.44 Å2
Dissociation energy (ΔGdiss): 3.35 kcal/mol
Dissociation entropy (TΔSdiss): 4.87 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155865
Assembly 2
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Assembly Name: MAP kinase-activated protein kinase 2
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Multimeric state: homo dodecamer
Accessible surface area: 145368.92 Å2
Buried surface area: 43999.79 Å2
Dissociation area: 6,999.03 Å2
Dissociation energy (ΔGdiss): 73.29 kcal/mol
Dissociation entropy (TΔSdiss): 48.77 kcal/mol
Symmetry number: 12
PDBe Complex ID: PDB-CPX-155867

Macromolecules

MAP kinase-activated protein kinase 2
Chain: A
Length: 400 amino acids
Theoretical weight: 45.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P49137 (Residues: 1-400; Coverage: 100%)
Gene name: MAPKAPK2
Pfam: Protein kinase domain
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
MAP kinase-activated protein kinase 2 in PDB entry 1ny3, assembly 1, front view.
MAP kinase-activated protein kinase 2 in PDB entry 1ny3, assembly 1, side view.
MAP kinase-activated protein kinase 2 in PDB entry 1ny3, assembly 1, top view.
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