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X-ray structure of the orphan nuclear receptor ERR3 ligand-binding domain in the constitutively active conformation

X-ray diffraction
2.7Å resolution
PDB entry 1kv6 coloured by chain, front view.
PDB entry 1kv6 coloured by chain, side view.
PDB entry 1kv6 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Estrogen-related receptor gamma and Nuclear receptor coactivator 1
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Multimeric state: hetero tetramer
Accessible surface area: 20845.68 Å2
Buried surface area: 4446.51 Å2
Dissociation area: 1,242.02 Å2
Dissociation energy (ΔGdiss): -1.51 kcal/mol
Dissociation entropy (TΔSdiss): 13.09 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-158635

Macromolecules

Estrogen-related receptor gamma
Chains: A, B
Length: 230 amino acids
Theoretical weight: 26.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P62508 (Residues: 229-458; Coverage: 50%)
Gene names: ERR3, ERRG2, ESRRG, KIAA0832, NR3B3
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor
SCOP: Nuclear receptor ligand-binding domain
Estrogen-related receptor gamma in PDB entry 1kv6, assembly 1, front view.
Estrogen-related receptor gamma in PDB entry 1kv6, assembly 1, side view.
Estrogen-related receptor gamma in PDB entry 1kv6, assembly 1, top view.
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Nuclear receptor coactivator 1
Chains: C, D
Length: 15 amino acids
Theoretical weight: 1.78 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15788 (Residues: 686-700; Coverage: 1%)
Gene names: BHLHE74, NCOA1, SRC1
InterPro:
Nuclear receptor coactivator 1 in PDB entry 1kv6, assembly 1, front view.
Nuclear receptor coactivator 1 in PDB entry 1kv6, assembly 1, side view.
Nuclear receptor coactivator 1 in PDB entry 1kv6, assembly 1, top view.
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