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PDBe Entry: 1hxk 
GOLGI ALPHA-MANNOSIDASE II IN COMPLEX WITH DEOXYMANNOJIRIMICIN
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HYDROLASE
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X-RAY DIFFRACTION
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Resolution: 1.5 Å, R-factor: 19.7%, Free R-factor: 21.6%, Spacegroup: P 21 21 21
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16/01/2002, deposition: 16/01/2001, last revision: 24/02/2009
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van den Elsen, J.M.H.; Kuntz, D.A.; Rose, D.R.
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Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells.
EMBO J. vol:20, pag:3008-3017 (2001) [PubMed ID 11406577 ]
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N-terminal alpha-beta domain, three helix bundle, 2 C-terminal beta barrels, HYDROLASE
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3.2.1.114 ExPASy BRENDA (A)
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Drosophila melanogaster(fruit fly) 7227(A)
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Alpha-mannosidase 2 (EC 3.2.1.114) (Alpha-mannosidase II) (AMAN II) (MAN II) (Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) (Golgi alpha-mannosidase II) Q24451 (A)
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A
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1hty, 1hww
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| A |
ALPHA-MANNOSIDASE II |
Protein |
Q24451 (MAN2_DROME)
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1015 |
99% |
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| A |
SUGAR (N-ACETYL-D-GLUCOSAMINE) |
NAG
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| A |
ZINC ION |
ZN
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| A |
1-DEOXYMANNOJIRIMYCIN |
DMJ
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| A |
(4R)-2-METHYLPENTANE-2,4-DIOL |
MRD
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