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STRUCTURE OF RUVB FROM THERMUS THERMOPHILUS HB8

Source organism: Thermus thermophilus
Biochemical function: ATP hydrolysis activity
Biological process: DNA duplex unwinding
Cellular component: Holliday junction resolvase complex

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EC 3.6.4.12: DNA helicase

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (DNA helix unwinding)
Alternative Name(s):
  • 3' to 5' DNA helicase
  • 3'-5' DNA helicase
  • 3'-5' PfDH
  • 5' to 3' DNA helicase
  • AvDH1
  • BACH1 helicase
  • BLM protein
  • BRCA1-associated C-terminal helicase
  • BcMCM
  • CeWRN-1
  • DNA helicase 120
  • DNA helicase A
  • DNA helicase E
  • DNA helicase II
  • DNA helicase III
  • DNA helicase RECQL5'
  • DNA helicase VI
  • Dbp9p
  • DmRECQ5
  • DnaB
  • DnaB helicase E1
  • HHcsA
  • HPif1
  • Hel E
  • Helicase DnaB
  • Helicase HDH IV
  • Helicase domain of bacteriophage T7 gene 4 protein helicase
  • Hmi1p
  • MCM helicase
  • MCM protein
  • MER3 helicase
  • MER3 protein
  • MPH1
  • PDH120
  • PIF1
  • PcrA
  • PcrA helicase
  • PfDH A
  • Pfh1p
  • UvrD

GO terms

Sequence families

Pfam Protein families (Pfam)
PF05491
Domain description: RuvB C-terminal winged helix domain
Occurring in:
  1. Holliday junction branch migration complex subunit RuvB
The deposited structure of PDB entry 1hqc contains 2 copies of Pfam domain PF05491 (RuvB C-terminal winged helix domain) in Holliday junction branch migration complex subunit RuvB. Showing 1 copy in chain A.

PF17864
Domain description: RuvB AAA lid domain
Occurring in:
  1. Holliday junction branch migration complex subunit RuvB
The deposited structure of PDB entry 1hqc contains 2 copies of Pfam domain PF17864 (RuvB AAA lid domain) in Holliday junction branch migration complex subunit RuvB. Showing 1 copy in chain A.

PF05496
Domain description: Holliday junction DNA helicase RuvB P-loop domain
Occurring in:
  1. Holliday junction branch migration complex subunit RuvB
The deposited structure of PDB entry 1hqc contains 2 copies of Pfam domain PF05496 (Holliday junction DNA helicase RuvB P-loop domain) in Holliday junction branch migration complex subunit RuvB. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR004605
Domain description: Holliday junction branch migration complex subunit RuvB
Occurring in:
  1. Holliday junction branch migration complex subunit RuvB
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Holliday junction branch migration complex subunit RuvB
IPR036388
Domain description: Winged helix-like DNA-binding domain superfamily
Occurring in:
  1. Holliday junction branch migration complex subunit RuvB
IPR036390
Domain description: Winged helix DNA-binding domain superfamily
Occurring in:
  1. Holliday junction branch migration complex subunit RuvB
IPR008823
Domain description: RuvB C-terminal winged helix domain
Occurring in:
  1. Holliday junction branch migration complex subunit RuvB
IPR041445
Domain description: RuvB, AAA lid domain
Occurring in:
  1. Holliday junction branch migration complex subunit RuvB
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. Holliday junction branch migration complex subunit RuvB
IPR008824
Domain description: RuvB-like P-loop domain
Occurring in:
  1. Holliday junction branch migration complex subunit RuvB

Structure domains

CATH CATH domains
1.10.10.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arc Repressor Mutant, subunit A
Homology: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Occurring in:
  1. Holliday junction branch migration complex subunit RuvB
The deposited structure of PDB entry 1hqc contains 2 copies of CATH domain 1.10.10.10 (Arc Repressor Mutant, subunit A) in Holliday junction branch migration complex subunit RuvB. Showing 1 copy in chain A.
1.10.8.60
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Helicase, Ruva Protein; domain 3
Homology: Helicase, Ruva Protein; domain 3
Occurring in:
  1. Holliday junction branch migration complex subunit RuvB
The deposited structure of PDB entry 1hqc contains 2 copies of CATH domain 1.10.8.60 (Helicase, Ruva Protein; domain 3) in Holliday junction branch migration complex subunit RuvB. Showing 1 copy in chain A.
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Holliday junction branch migration complex subunit RuvB
The deposited structure of PDB entry 1hqc contains 2 copies of CATH domain 3.40.50.300 (Rossmann fold) in Holliday junction branch migration complex subunit RuvB. Showing 1 copy in chain A.
SCOP SCOP annotations
46819
Class: All alpha proteins
Fold: DNA/RNA-binding 3-helical bundle
Superfamily: "Winged helix" DNA-binding domain
Occurring in:
  1. Holliday junction branch migration complex subunit RuvB
The deposited structure of PDB entry 1hqc contains 2 copies of SCOP domain 46819 (Helicase DNA-binding domain) in Holliday junction branch migration complex subunit RuvB. Showing 1 copy in chain A.
81269
Class: Alpha and beta proteins (a/b)
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Occurring in:
  1. Holliday junction branch migration complex subunit RuvB
The deposited structure of PDB entry 1hqc contains 2 copies of SCOP domain 81269 (Extended AAA-ATPase domain) in Holliday junction branch migration complex subunit RuvB. Showing 1 copy in chain A.

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