1hho Summary

pdbe.org/1hho
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STRUCTURE OF HUMAN OXYHAEMOGLOBIN AT 2.1 ANGSTROMS RESOLUTION

The structure was published by Shaanan, B., in 1983 in a paper entitled "Structure of human oxyhaemoglobin at 2.1 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1983.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN A (OXY) (ALPHA CHAIN) and HEMOGLOBIN A (OXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN A (OXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN A (OXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN A (OXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN A (OXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P69905) oxygen bindingsearch protein bindingsearch iron ion bindingsearch heme bindingsearch peroxidase activitysearch metal ion bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch hemoglobin complexsearch blood microparticlesearch endocytic vesicle lumensearch cytosolic small ribosomal subunitsearch extracellular regionsearch membranesearch extracellular vesicular exosomesearch cytosolsearch haptoglobin-hemoglobin complexsearch response to hydrogen peroxidesearch positive regulation of cell deathsearch bicarbonate transportsearch protein heterooligomerizationsearch oxygen transportsearch hydrogen peroxide catabolic processsearch oxidation-reduction processsearch transportsearch small molecule metabolic processsearch
B (P68871) oxygen bindingsearch haptoglobin bindingsearch hemoglobin bindingsearch iron ion bindingsearch heme bindingsearch peroxidase activitysearch protein bindingsearch oxygen transporter activitysearch metal ion bindingsearch hemoglobin complexsearch cytosolsearch extracellular regionsearch extracellular vesicular exosomesearch blood microparticlesearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch transportsearch oxygen transportsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch nitric oxide transportsearch renal absorptionsearch blood coagulationsearch regulation of blood vessel sizesearch positive regulation of cell deathsearch platelet aggregationsearch oxidation-reduction processsearch positive regulation of nitric oxide biosynthetic processsearch small molecule metabolic processsearch response to hydrogen peroxidesearch regulation of blood pressuresearch protein heterooligomerizationsearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch