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X-RAY CRYSTAL STRUCTURE OF THE PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR

X-ray diffraction
1.5Å resolution
PDB entry 1aap coloured by chain, front view.
PDB entry 1aap coloured by chain, side view.
PDB entry 1aap coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Amyloid-beta protein 42 complex
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Multimeric state: homo dimer
Accessible surface area: 7082.34 Å2
Buried surface area: 720.31 Å2
Dissociation area: 360.15 Å2
Dissociation energy (ΔGdiss): -5.29 kcal/mol
Dissociation entropy (TΔSdiss): 9.66 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-138395
Complex Portal ID: CPX-1070

Macromolecules

Soluble APP-beta
Chains: A, B
Length: 58 amino acids
Theoretical weight: 6.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05067 (Residues: 287-344; Coverage: 8%)
Gene names: A4, AD1, APP
Pfam: Kunitz/Bovine pancreatic trypsin inhibitor domain
InterPro:
CATH: Pancreatic trypsin inhibitor Kunitz domain
SCOP: Small Kunitz-type inhibitors & BPTI-like toxins
Soluble APP-beta in PDB entry 1aap, assembly 1, front view.
Soluble APP-beta in PDB entry 1aap, assembly 1, side view.
Soluble APP-beta in PDB entry 1aap, assembly 1, top view.
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