1a3n Summary

pdbe.org/1a3n
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DEOXY HUMAN HEMOGLOBIN

The structure was published by Tame, J.R. and Vallone, B., in 2000 in a paper entitled "The structures of deoxy human haemoglobin and the mutant Hb Tyralpha42His at 120 K." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (ALPHA CHAIN) and HEMOGLOBIN (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 99%
D HEMOGLOBIN (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 99%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) protein bindingsearch metal ion bindingsearch oxygen bindingsearch heme bindingsearch iron ion bindingsearch haptoglobin bindingsearch peroxidase activitysearch oxygen transporter activitysearch extracellular regionsearch extracellular vesicular exosomesearch membranesearch cytosolic small ribosomal subunitsearch hemoglobin complexsearch cytosolsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch blood microparticlesearch oxygen transportsearch small molecule metabolic processsearch bicarbonate transportsearch transportsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch positive regulation of cell deathsearch
B, D (P68871) protein bindingsearch oxygen bindingsearch oxygen transporter activitysearch hemoglobin bindingsearch iron ion bindingsearch heme bindingsearch metal ion bindingsearch peroxidase activitysearch haptoglobin bindingsearch cytosolsearch extracellular vesicular exosomesearch blood microparticlesearch extracellular regionsearch endocytic vesicle lumensearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch nitric oxide transportsearch hydrogen peroxide catabolic processsearch regulation of blood vessel sizesearch positive regulation of cell deathsearch transportsearch oxygen transportsearch positive regulation of nitric oxide biosynthetic processsearch oxidation-reduction processsearch bicarbonate transportsearch blood coagulationsearch renal absorptionsearch platelet aggregationsearch protein heterooligomerizationsearch regulation of blood pressuresearch response to hydrogen peroxidesearch small molecule metabolic processsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch